Literature DB >> 34221226

Koilonychia in a Patient with Alopecia Areata.

Noureddine Litaiem1, Olfa Charfi1, Takwa Bacha1, Faten Zeglaoui1.   

Abstract

Alopecia areata (AA) is an autoimmune disease that affects the hair follicles and leads to nonscarring alopecia. Nails changes are a common manifestation in AA, with an average prevalence of 30 percent. Both nail changes and hair loss in AA are associated with lymphocytic inflammation and are thought to be a result of a loss of immune privilege in both hair follicle and nail apparatus. Koilonychia, or "spoon nails," is a nail dystrophy where the nail plate is depressed centrally and everted laterally. Causes of nail spooning are various, but koilonychia is usually associated with iron deficiency and inflammatory dermatoses, such as psoriasis and lichen planus. Koilonychia is very rarely reported in association with AA in the English literature and its prognostic significance is still unknown. We report a case of a 25-year-old female patient who presented with AA focalis and koilonychia that regressed almost completely after oral corticosteroids, with an accompanying discussion of the pathogenesis and prognostic value of koilonychia.
Copyright © 2021. Matrix Medical Communications. All rights reserved.

Entities:  

Keywords:  Alopecia areata; koilonychia; nail changes

Year:  2021        PMID: 34221226      PMCID: PMC8211338     

Source DB:  PubMed          Journal:  J Clin Aesthet Dermatol        ISSN: 1941-2789


  7 in total

1.  Tofacitinib Citrate for the Treatment of Nail Dystrophy Associated With Alopecia Universalis.

Authors:  Arjun Dhayalan; Brett A King
Journal:  JAMA Dermatol       Date:  2016-04       Impact factor: 10.282

Review 2.  Nail changes in alopecia areata: an update and review.

Authors:  Khatiya Chelidze; Shari R Lipner
Journal:  Int J Dermatol       Date:  2018-01-10       Impact factor: 2.736

3.  Immunology of the human nail apparatus: the nail matrix is a site of relative immune privilege.

Authors:  Taisuke Ito; Natsuho Ito; Matthias Saathoff; Barbara Stampachiacchiere; Albrecht Bettermann; Sylvia Bulfone-Paus; Masahiro Takigawa; Brian J Nickoloff; Ralf Paus
Journal:  J Invest Dermatol       Date:  2005-12       Impact factor: 8.551

4.  Nail changes in alopecia areata: frequency and clinical presentation.

Authors:  E Kasumagic-Halilovic; A Prohic
Journal:  J Eur Acad Dermatol Venereol       Date:  2008-06-01       Impact factor: 6.166

Review 5.  Nail Involvement in Alopecia Areata: A Questionnaire-based Survey on Clinical Signs, Impact on Quality of Life and Review of the Literature.

Authors:  Yvonne B M Roest; Henrià T van Middendorp; Andrea W M Evers; Peter C M van de Kerkhof; Marcel C Pasch
Journal:  Acta Derm Venereol       Date:  2018-02-07       Impact factor: 4.437

Review 6.  Koilonychia: an update on pathophysiology, differential diagnosis and clinical relevance.

Authors:  J Walker; R Baran; N Vélez; N Jellinek
Journal:  J Eur Acad Dermatol Venereol       Date:  2016-08-17       Impact factor: 6.166

7.  Trachyonychia associated with alopecia areata: a clinical and pathologic study.

Authors:  A Tosti; P A Fanti; R Morelli; F Bardazzi
Journal:  J Am Acad Dermatol       Date:  1991-08       Impact factor: 11.527

  7 in total
  1 in total

1.  Recovery of Alopecia Universalis with Associated Nail Dystrophy Treated with Tofacitinib: A 6-year-old Child's Case Report.

Authors:  Vineet Dube
Journal:  Int J Trichology       Date:  2021-11-22
  1 in total

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