Meena Ramesh Chand1, Nagina Agarwal2, Dev Nishanth1, Sankar Jhuma3. 1. Department of Internal Medicine, VMMC & Safdarjung Hospital, New Delhi, India. 2. Department of Internal Medicine, ABVIMS & RML Hospital, New Delhi, India. 3. Department of Pediatrics, AIIMS, Delhi, India.
Abstract
Background: Metabolic syndrome is a known risk factor for various diseases including coronary artery disease and is associated with subclinical-inflammation. Various inflammatory markers have been evaluated in metabolic syndrome. However, the data evaluating serum ferritin in metabolic syndrome is sparse. The current study aims to evaluate the correlation between serum ferritin and metabolic syndrome. Materials and methods:This cross-sectional study included 100 subjects with metabolic syndrome and 50 gender matched healthy controls. Results: The mean age (SD) in study and control groups was 52.34 (7.64) and 48.36 (9.16) years, respectively. Majority were females in both groups (60% vs 52%). The mean (SD) HbA1c amongst study vs control was 8.26 (2.33) vs 5.10 (0.51); <0.0001. Mean (SD) serum iron and hsCRP were significantly higher in the study group (115.50 ±42.6 vs 65.741±9.16; p<0.001) and (6.33±4.87 vs 3.45±3.5; p<0.007) respectively. Mean serum ferritin level was significantly higher in the study group (123.9 vs 59.02; p<0.0001). A statistically significant correlation was found between serum ferritin and waist hip ratio, triglyceride, BMI and HOMA IR (r=0.49, p<0.0001; r=0.50, p<0.0001; r=0.47, p<0.0001 and r=0.54, p<0.0001 respectively). An inverse correlation was found between serum ferritin and serum HDL levels (r=-0.46, p<0.0001). Even after adjusting for age, serum ferritin levels were found to be significantly associated with metabolic syndrome Coeff (95% CI) -65.6 (-84.23, -46.98); p<0.0001. Conclusion: Significantly higher levels of serum ferritin were found in metabolic syndrome, and a significant correlation with its components was seen. Therefore, serum ferritin may be used as a marker of inflammation for an early intervention.
Background: Metabolic syndrome is a known risk factor for various diseases including coronary artery disease and is associated with subclinical-inflammation. Various inflammatory markers have been evaluated in metabolic syndrome. However, the data evaluating serum ferritin in metabolic syndrome is sparse. The current study aims to evaluate the correlation between serum ferritin and metabolic syndrome. Materials and methods:This cross-sectional study included 100 subjects with metabolic syndrome and 50 gender matched healthy controls. Results: The mean age (SD) in study and control groups was 52.34 (7.64) and 48.36 (9.16) years, respectively. Majority were females in both groups (60% vs 52%). The mean (SD) HbA1c amongst study vs control was 8.26 (2.33) vs 5.10 (0.51); <0.0001. Mean (SD) serum iron and hsCRP were significantly higher in the study group (115.50 ±42.6 vs 65.741±9.16; p<0.001) and (6.33±4.87 vs 3.45±3.5; p<0.007) respectively. Mean serum ferritin level was significantly higher in the study group (123.9 vs 59.02; p<0.0001). A statistically significant correlation was found between serum ferritin and waist hip ratio, triglyceride, BMI and HOMA IR (r=0.49, p<0.0001; r=0.50, p<0.0001; r=0.47, p<0.0001 and r=0.54, p<0.0001 respectively). An inverse correlation was found between serum ferritin and serum HDL levels (r=-0.46, p<0.0001). Even after adjusting for age, serum ferritin levels were found to be significantly associated with metabolic syndrome Coeff (95% CI) -65.6 (-84.23, -46.98); p<0.0001. Conclusion: Significantly higher levels of serum ferritin were found in metabolic syndrome, and a significant correlation with its components was seen. Therefore, serum ferritin may be used as a marker of inflammation for an early intervention.
Authors: J M Fernández-Real; W Ricart-Engel; E Arroyo; R Balançá; R Casamitjana-Abella; D Cabrero; M Fernández-Castañer; J Soler Journal: Diabetes Care Date: 1998-01 Impact factor: 19.112
Authors: Thang S Han; Naveed Sattar; Ken Williams; Clicerio Gonzalez-Villalpando; Michael E J Lean; Steven M Haffner Journal: Diabetes Care Date: 2002-11 Impact factor: 19.112
Authors: C Niederau; M Berger; W Stremmel; A Starke; G Strohmeyer; R Ebert; E Siegel; W Creutzfeldt Journal: Diabetologia Date: 1984-06 Impact factor: 10.122
Authors: Naveed Sattar; Allan Gaw; Olga Scherbakova; Ian Ford; Denis St J O'Reilly; Steven M Haffner; Chris Isles; Peter W Macfarlane; Chris J Packard; Stuart M Cobbe; James Shepherd Journal: Circulation Date: 2003-07-14 Impact factor: 29.690
Authors: Päivi Hämäläinen; Juha Saltevo; Hannu Kautiainen; Pekka Mäntyselkä; Mauno Vanhala Journal: Diabetol Metab Syndr Date: 2014-10-26 Impact factor: 3.320