Literature DB >> 34219053

Targeting Serine in Cancer: Is Two Better Than One?

Aitziber Buqué1, Lorenzo Galluzzi2, David C Montrose3.   

Abstract

Several recent preclinical studies have demonstrated that simultaneously blocking exogenous and endogenous sources of serine in malignant cells mediates superior anticancer effects as compared with limiting either source alone. Here, we critically summarize key developments in targeting serine to treat cancer and discuss persisting challenges for implementing such a therapeutic approach in patients.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  DNA damage; PHGDH; PSAT1; PSPH; colorectal cancer; glycine

Mesh：

Substances：

Year:  2021        PMID： 34219053      PMCID： PMC9097339          DOI： 10.1016/j.trecan.2021.06.004

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  12 in total

1.  Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate.

Authors:  Preethi Korangath; Wei Wen Teo; Helen Sadik; Liangfeng Han; Noriko Mori; Charlotte M Huijts; Flonne Wildes; Santosh Bharti; Zhe Zhang; Cesar A Santa-Maria; Hualing Tsai; Chi V Dang; Vered Stearns; Zaver M Bhujwalla; Saraswati Sukumar
Journal:  Clin Cancer Res       Date:  2015-03-26       Impact factor: 12.531

Review 2.  Drugging cancer metabolism: Expectations vs. reality.

Authors:  David C Montrose; Lorenzo Galluzzi
Journal:  Int Rev Cell Mol Biol       Date:  2019-07-29       Impact factor: 6.813

3.  Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting.

Authors:  Mark R Sullivan; Katherine R Mattaini; Emily A Dennstedt; Anna A Nguyen; Sharanya Sivanand; Montana F Reilly; Katrina Meeth; Alexander Muir; Alicia M Darnell; Marcus W Bosenberg; Caroline A Lewis; Matthew G Vander Heiden
Journal:  Cell Metab       Date:  2019-03-21       Impact factor: 27.287

4.  Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.

Authors:  Jason M Rohde; Kyle R Brimacombe; Li Liu; Michael E Pacold; Adam Yasgar; Dorian M Cheff; Tobie D Lee; Ganesha Rai; Bolormaa Baljinnyam; Zhuyin Li; Anton Simeonov; Matthew D Hall; Min Shen; David M Sabatini; Matthew B Boxer
Journal:  Bioorg Med Chem       Date:  2018-02-27       Impact factor: 3.641

5.  Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer.

Authors:  Robert S Banh; Douglas E Biancur; Keisuke Yamamoto; Albert S W Sohn; Beth Walters; Miljan Kuljanin; Ajami Gikandi; Huamin Wang; Joseph D Mancias; Robert J Schneider; Michael E Pacold; Alec C Kimmelman
Journal:  Cell       Date:  2020-11-02       Impact factor: 41.582

6.  Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition.

Authors:  Bryan Ngo; Eugenie Kim; Victoria Osorio-Vasquez; Sophia Doll; Sophia Bustraan; Roger J Liang; Alba Luengo; Shawn M Davidson; Ahmed Ali; Gino B Ferraro; Grant M Fischer; Roozbeh Eskandari; Diane S Kang; Jing Ni; Ariana Plasger; Vinagolu K Rajasekhar; Edward R Kastenhuber; Sarah Bacha; Roshan K Sriram; Benjamin D Stein; Samuel F Bakhoum; Matija Snuderl; Paolo Cotzia; John H Healey; Nello Mainolfi; Vipin Suri; Adam Friedman; Mark Manfredi; David M Sabatini; Drew R Jones; Min Yu; Jean J Zhao; Rakesh K Jain; Kayvan R Keshari; Michael A Davies; Matthew G Vander Heiden; Eva Hernando; Matthias Mann; Lewis C Cantley; Michael E Pacold
Journal:  Cancer Discov       Date:  2020-06-22       Impact factor: 39.397

Review 7.  Metabolic Reprogramming in Anticancer Drug Resistance: A Focus on Amino Acids.

Authors:  Erica Pranzini; Elisa Pardella; Paolo Paoli; Sarah-Maria Fendt; Maria Letizia Taddei
Journal:  Trends Cancer       Date:  2021-03-15

8.  Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil.

Authors:  David C Montrose; Suchandrima Saha; Miguel Foronda; Erin M McNally; Justin Chen; Xi Kathy Zhou; Taehoon Ha; Jan Krumsiek; Mustafa Buyukozkan; Akanksha Verma; Olivier Elemento; Rhonda K Yantiss; Qiuying Chen; Steven S Gross; Lorenzo Galluzzi; Lukas E Dow; Andrew J Dannenberg
Journal:  Cancer Res       Date:  2021-02-01       Impact factor: 13.312

9.  Identifying strategies to target the metabolic flexibility of tumours.

Authors:  Andrés Méndez-Lucas; Wei Lin; Paul C Driscoll; Nathalie Legrave; Laura Novellasdemunt; Chencheng Xie; Mark Charles; Zena Wilson; Neil P Jones; Stephen Rayport; Manuel Rodríguez-Justo; Vivian Li; James I MacRae; Nissim Hay; Xin Chen; Mariia Yuneva
Journal:  Nat Metab       Date:  2020-04-21

10.  Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Authors:  Oliver D K Maddocks; Celia R Berkers; Susan M Mason; Liang Zheng; Karen Blyth; Eyal Gottlieb; Karen H Vousden
Journal:  Nature       Date:  2012-12-16       Impact factor: 49.962
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.