Thora Ying Li Chai1, Romesh Mark Rajaratnam2, Difei Deng3, Jacob George4, Dharmintra Pasupathy5, Ngai Wah Cheung6. 1. Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. Electronic address: thora.chai@sydney.edu.au. 2. Department of Diabetes and Endocrinology, Nepean Hospital, Kingswood, Australia. 3. Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Department of Diabetes and Endocrinology, Nepean Hospital, Kingswood, Australia. 4. Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Storr Liver Centre, Westmead Millennium Institute for Medical Research, Westmead, Australia; Department of Gastroenterology and Hepatology, Westmead Hospital, Westmead, Australia. 5. Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Specialty of Obstetrics, Gynaecology and Neonatology, Westmead Hospital, Westmead, Australia. 6. Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Abstract
AIMS: To further explore the relationship between non-alcoholic fatty liver disease (NAFLD) and gestational diabetes mellitus (GDM) by determining the prevalence of GDM in women diagnosed with NAFLD antepartum. METHODS: Electronic databases were searched using specific keywords. Original studies of adult women reporting NAFLD (confirmed on imaging) and GDM (confirmed via oral glucose tolerance test) prevalence were included. Studies involving women with pre-gestational pre-diabetes, type 1/type 2 diabetes, chronic liver disease/cirrhosis unrelated to NAFLD were excluded. The prevalence of GDM occurring in women with NAFLD was calculated along with pooled odds ratios and 95% confidence intervals (CI) using the random effects model. RESULTS: Seven studies (total 2299 participants) were included. The prevalence of GDM in women with NAFLD was 26.0% (95% CI 20.9-31.7%, I2 = 48%, τ2 = 0.06). The odds of having GDM were 2.9 times higher in pregnant women diagnosed with NAFLD compared with non-NAFLD women, although a high degree of heterogeneity existed (unadjusted OR 2.9, 95% CI 1.0-8.4, I2 = 81%, τ2 = 0.83, p < 0.05). CONCLUSION: Our study provides further insight into the prevalence of GDM in pregnant women diagnosed with NAFLD. There is a current lack of well-conducted studies examining this complex association between NAFLD and GDM.
AIMS: To further explore the relationship between non-alcoholic fatty liver disease (NAFLD) and gestational diabetes mellitus (GDM) by determining the prevalence of GDM in women diagnosed with NAFLD antepartum. METHODS: Electronic databases were searched using specific keywords. Original studies of adult women reporting NAFLD (confirmed on imaging) and GDM (confirmed via oral glucose tolerance test) prevalence were included. Studies involving women with pre-gestational pre-diabetes, type 1/type 2 diabetes, chronic liver disease/cirrhosis unrelated to NAFLD were excluded. The prevalence of GDM occurring in women with NAFLD was calculated along with pooled odds ratios and 95% confidence intervals (CI) using the random effects model. RESULTS: Seven studies (total 2299 participants) were included. The prevalence of GDM in women with NAFLD was 26.0% (95% CI 20.9-31.7%, I2 = 48%, τ2 = 0.06). The odds of having GDM were 2.9 times higher in pregnant women diagnosed with NAFLD compared with non-NAFLD women, although a high degree of heterogeneity existed (unadjusted OR 2.9, 95% CI 1.0-8.4, I2 = 81%, τ2 = 0.83, p < 0.05). CONCLUSION: Our study provides further insight into the prevalence of GDM in pregnant women diagnosed with NAFLD. There is a current lack of well-conducted studies examining this complex association between NAFLD and GDM.