Haiyan Su1, Tong Liu2, Yupeng Li2, Yuxin Fan3, Baoping Wang2, Ming Liu2, Gang Hu4, Zhaowei Meng5, Qing Zhang6. 1. Department of Health Management, Tianjin Medical University General Hospital, Tianjin, China. 2. Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China. 3. Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China; Pennington Biomedical Research Center, Baton Rouge, LA, USA. 4. Pennington Biomedical Research Center, Baton Rouge, LA, USA. Electronic address: gang.hu@pbrc.edu. 5. Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: zmeng@tmu.edu.cn. 6. Department of Health Management, Tianjin Medical University General Hospital, Tianjin, China. Electronic address: zhang_65q@163.com.
Abstract
OBJECTIVE: To assess the association of baseline uric acid levels and their changes from baseline to Year 1 with the risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: This study cohort included 9471 subjects without a history of diabetes at baseline. The incident diabetes was diagnosed according to the American Diabetes Association standard. RESULTS: During a mean follow-up of 2.9 years, we identified 762 type 2 diabetes cases. Multivariate-adjusted hazard ratios (HRs) of diabetes across baseline tertiles of serum uric acid were 1.00, 1.15, and 1.32 (P for trend = 0.018), respectively. Participants with hyperuricemia compared with those without had a 1.20-fold (95% confidence interval [CI] 1.01-1.44) risk of diabetes. When uric acid was examined as a continuous variable, multivariable-adjusted HR of diabetes for each 1 mg/dL (60 μmol/L) increase in serum uric acid was 1.09 (95% CI 1.03-1.15). Compared with subjects with stable serum uric acid from baseline to Year 1 (±10%), those with uric acid gain ≥30% had a 30% (95% CI 1.01-1.79) increased risk of diabetes and those with uric acid loss ≥10% had a 21% (95% 0.62-0.99) decreased risk of diabetes. This positive association between baseline serum uric acid and diabetes risk was consistent among subjects younger and older than 45 years, non-obese and obese participants, and men. CONCLUSIONS: High level of baseline serum uric acid and serum uric acid gain from baseline to Year 1 are associated with an increased risk of type 2 diabetes among Chinese adults.
OBJECTIVE: To assess the association of baseline uric acid levels and their changes from baseline to Year 1 with the risk of type 2 diabetes. RESEARCH DESIGN AND METHODS: This study cohort included 9471 subjects without a history of diabetes at baseline. The incident diabetes was diagnosed according to the American Diabetes Association standard. RESULTS: During a mean follow-up of 2.9 years, we identified 762 type 2 diabetes cases. Multivariate-adjusted hazard ratios (HRs) of diabetes across baseline tertiles of serum uric acid were 1.00, 1.15, and 1.32 (P for trend = 0.018), respectively. Participants with hyperuricemia compared with those without had a 1.20-fold (95% confidence interval [CI] 1.01-1.44) risk of diabetes. When uric acid was examined as a continuous variable, multivariable-adjusted HR of diabetes for each 1 mg/dL (60 μmol/L) increase in serum uric acid was 1.09 (95% CI 1.03-1.15). Compared with subjects with stable serum uric acid from baseline to Year 1 (±10%), those with uric acid gain ≥30% had a 30% (95% CI 1.01-1.79) increased risk of diabetes and those with uric acid loss ≥10% had a 21% (95% 0.62-0.99) decreased risk of diabetes. This positive association between baseline serum uric acid and diabetes risk was consistent among subjects younger and older than 45 years, non-obese and obese participants, and men. CONCLUSIONS: High level of baseline serum uric acid and serum uric acid gain from baseline to Year 1 are associated with an increased risk of type 2 diabetes among Chinese adults.