| Literature DB >> 34212423 |
Shinichi Watanabe1, Ken Iozumi2, Masatoshi Abe3, Yoshiko Ito4, Takashi Uesugi5, Takashi Onoduka6, Ichiro Kato7, Fumihiro Kato8, Kazuo Kodama9, Hidetoshi Takahashi10, Osamu Takeda11, Koki Tomizawa12, Yasuki Tateishi13, Mizue Fujii14, Jun Mayama15, Fumio Muramoto16, Hidemi Yasuda17, Kiyomitsu Yamanaka18, Tsunao Oh-I19, Hiroko Kasai20, Ryoji Tsuboi21, Naoko Hattori22, Ryuji Maruyama23, Tokuya Omi24, Harunari Shimoyama25, Ichiro Nakasu26, Emiko Watanabe-Okada27,28, Shuhei Nishimoto29, Takashi Mochizuki30, Masao Fukuzawa31, Mariko Seishima32, Kazumitsu Sugiura33, Osamu Yamamoto34, Masahisa Shindo35, Hiroe Kiryu36, Masahiro Kusuhara37, Motoi Takenaka38.
Abstract
Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.Entities:
Keywords: dermatophytoma; efinaconazole; longitudinal spike; onychomycosis; topical triazole antifungal
Year: 2021 PMID： 34212423 DOI： 10.1111/1346-8138.16035
Source DB: PubMed Journal: J Dermatol ISSN： 0385-2407 Impact factor: 4.005