Karin C Wu1,2, Susan K Ewing3, Xiaojuan Li4, Sigurður Sigurðsson5, Vilmundur Guðnason5,6, Deborah M Kado7,8, Trisha F Hue3, Gina N Woods9,10, Annegreet G Veldhuis-Vlug11,12, Eric Vittinghoff3, Mone Zaidi13, Clifford J Rosen11, Thomas Lang14, Tiffany Y Kim1,2, Ann V Schwartz3, Anne L Schafer1,2,3. 1. Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA. 2. Endocrine Research Unit, San Francisco Veterans Affairs Health Care System, San Francisco, CA 94121, USA. 3. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94143, USA. 4. Program of Advanced Musculoskeletal Imaging, Cleveland Clinic, Cleveland, OH 44195, USA. 5. Icelandic Heart Association Research Institute, 201 Kópavogur, Iceland. 6. Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 7. Department of Medicine, Stanford University, Stanford, CA 94305, USA. 8. Geriatric Research Education and Clinical Center, Veterans Affairs Health Care System, Palo Alto, CA 94304, USA. 9. Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA. 10. Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA. 11. Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME 04074, USA. 12. Center for Bone Quality, Department of Endocrinology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. 13. The Mount Sinai Bone Program and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. 14. Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Abstract
CONTEXT: FSH may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. OBJECTIVE: We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. SETTING, DESIGN, PARTICIPANTS: We studied 162 women and 158 men (mean age 82 ± 4 years) from the Age, Gene/Environment Susceptibility (AGES)-Bone Marrow Adiposity cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. MAIN OUTCOMES: Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. RESULTS: There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7 to 3.3) mg/cm2/y in women, and -0.2 (-2.6 to 2.2) mg/cm2/y in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03 to 3.62) cm2/y in women, and -0.33 (-3.73 to 3.06) cm2/y in men. CONCLUSIONS: Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes. Published by Oxford University Press on behalf of the Endocrine Society 2021.
CONTEXT: FSH may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. OBJECTIVE: We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. SETTING, DESIGN, PARTICIPANTS: We studied 162 women and 158 men (mean age 82 ± 4 years) from the Age, Gene/Environment Susceptibility (AGES)-Bone Marrow Adiposity cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. MAIN OUTCOMES: Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. RESULTS: There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7 to 3.3) mg/cm2/y in women, and -0.2 (-2.6 to 2.2) mg/cm2/y in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03 to 3.62) cm2/y in women, and -0.33 (-3.73 to 3.06) cm2/y in men. CONCLUSIONS: Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes. Published by Oxford University Press on behalf of the Endocrine Society 2021.
Entities:
Keywords:
adiposity; aging; body composition; bone loss; follicle-stimulating hormone (FSH)
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