Yao Zhang1, Zirui He2, Fan Yang3, Changqing Ye3, Xia Xu3, Shige Wang3, Ling Zhang1, Duowu Zou1. 1. Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.197, Rui Jin Er Road, Shanghai 200025, China. 2. Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No.197, Rui Jin Er Road, Shanghai 200025, China. 3. College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China.
Abstract
BACKGROUND: We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS2 nanosheets for postoperative tumor re-occurrence inhibition. However, owing to that the nanofibrous mat is un-injectable, this composite nanofiber is far from being clinically applicable. MATERIALS AND METHODS: Via modulating the electrospray parameters, polyvinyl alcohol (PVA) beads string doped with DOX and MoS2 (PVA/MoS2/DOX microspheres) were prepared, which were further crosslinked with glutaraldehyde to obtain the water-stability. RESULTS: Under the 808-nm laser irradiation, MoS2 nanosheets rendered the prepared PVA/MoS2/DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. Besides, the heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres. CONCLUSION: PVA/MoS2/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS2/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer.
BACKGROUND: We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS2 nanosheets for postoperative tumor re-occurrence inhibition. However, owing to that the nanofibrous mat is un-injectable, this composite nanofiber is far from being clinically applicable. MATERIALS AND METHODS: Via modulating the electrospray parameters, polyvinyl alcohol (PVA) beads string doped with DOX and MoS2 (PVA/MoS2/DOX microspheres) were prepared, which were further crosslinked with glutaraldehyde to obtain the water-stability. RESULTS: Under the 808-nm laser irradiation, MoS2 nanosheets rendered the prepared PVA/MoS2/DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. Besides, the heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres. CONCLUSION:PVA/MoS2/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS2/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer.
Authors: Khaled El-Shami; Kevin C Oeffinger; Nicole L Erb; Anne Willis; Jennifer K Bretsch; Mandi L Pratt-Chapman; Rachel S Cannady; Sandra L Wong; Johnie Rose; April L Barbour; Kevin D Stein; Katherine B Sharpe; Durado D Brooks; Rebecca L Cowens-Alvarado Journal: CA Cancer J Clin Date: 2015-09-08 Impact factor: 508.702