Modesto M Maestre-Muñiz1,2, Ángel Arias3,4,5, Emilia Mata-Vázquez1, María Martín-Toledano1, Germán López-Larramona1, Ana María Ruiz-Chicote1, Bárbara Nieto-Sandoval1, Alfredo J Lucendo4,5,6. 1. Department of Internal Medicine, Hospital General de Tomelloso, 13700 Ciudad Real, Spain. 2. Department of Medicine and Medical Specialties, Universidad de Alcalá, 28801 Alcalá de Henares, Spain. 3. Hospital General La Mancha Centro, Research Unit, Alcázar de San Juan, 13600 Ciudad Real, Spain. 4. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain. 5. Instituto de Investigación Sanitaria La Princesa, 28006 Madrid, Spain. 6. Department of Gastroenterology, Hospital General de Tomelloso, 13700 Ciudad Real, Spain.
Abstract
BACKGROUND: The long-term effects of COVID-19 remain largely unclear. This study aims to investigate post-acute health consequences and mortality one year after hospital discharge. METHODS: All surviving adult patients who were discharged after hospital admission due to acute COVID-19 in the first wave of the pandemic underwent a comprehensive interview. Functional assessment was performed in patients aged over 65. Clinical and hospital records were reviewed and mortality causes assessed. RESULTS: A total of 587 patients with COVID-19 were discharged from hospital, including 266 after hospital admission and 321 from the emergency room. Mortality within the following year occurred in 34/266 (12.8%) and 10/321 (3.1%), respectively, due to causes directly or possibly related to COVID-19 in 20.5% and 25% of patients. Post-COVID-19 syndrome was assessed in 543 patients at one year from discharge. Any clinical complaint was reported by 90.1% of patients who needed hospitalization and 80.4% of those discharged from the emergency room (p = 0.002), with breathlessness (41.6%), tiredness (35.4%), ageusia (30.2%), and anosmia (26.3%) being the most common complaints. Ongoing symptoms attributed to COVID-19 were reported by 66.8% and 49.5% of patients, respectively (p < 0.001). Newly developed COPD, asthma, diabetes, heart failure, and arthritis-as well as worsening of preexisting comorbidities-were found. CONCLUSIONS: One-year mortality among survivors of acute COVID-19 was 7.5%. A significant proportion of COVID-19 patients experienced ongoing symptoms at 1 year from onset of the disease.
BACKGROUND: The long-term effects of COVID-19 remain largely unclear. This study aims to investigate post-acute health consequences and mortality one year after hospital discharge. METHODS: All surviving adult patients who were discharged after hospital admission due to acute COVID-19 in the first wave of the pandemic underwent a comprehensive interview. Functional assessment was performed in patients aged over 65. Clinical and hospital records were reviewed and mortality causes assessed. RESULTS: A total of 587 patients with COVID-19 were discharged from hospital, including 266 after hospital admission and 321 from the emergency room. Mortality within the following year occurred in 34/266 (12.8%) and 10/321 (3.1%), respectively, due to causes directly or possibly related to COVID-19 in 20.5% and 25% of patients. Post-COVID-19 syndrome was assessed in 543 patients at one year from discharge. Any clinical complaint was reported by 90.1% of patients who needed hospitalization and 80.4% of those discharged from the emergency room (p = 0.002), with breathlessness (41.6%), tiredness (35.4%), ageusia (30.2%), and anosmia (26.3%) being the most common complaints. Ongoing symptoms attributed to COVID-19 were reported by 66.8% and 49.5% of patients, respectively (p < 0.001). Newly developed COPD, asthma, diabetes, heart failure, and arthritis-as well as worsening of preexisting comorbidities-were found. CONCLUSIONS: One-year mortality among survivors of acute COVID-19 was 7.5%. A significant proportion of COVID-19patients experienced ongoing symptoms at 1 year from onset of the disease.
Authors: Rupert Jones; Andrew Davis; Brooklyn Stanley; Steven Julious; Dermot Ryan; David J Jackson; David M G Halpin; Katherine Hickman; Hilary Pinnock; Jennifer K Quint; Kamlesh Khunti; Liam G Heaney; Phillip Oliver; Salman Siddiqui; Ian Pavord; David H M Jones; Michael Hyland; Lewis Ritchie; Pam Young; Tony Megaw; Steve Davis; Samantha Walker; Stephen Holgate; Sue Beecroft; Anu Kemppinen; Francis Appiagyei; Emma-Jane Roberts; Megan Preston; Antony Hardjojo; Victoria Carter; Marije van Melle; David Price Journal: Pragmat Obs Res Date: 2021-08-11