| Literature DB >> 34208464 |
Xia Xu1,2,3,4, Shuyu Liu1,2,3,4, Hua Liu1,2,3,4, Kang Ru1,2,3,4, Yunxian Jia1,2,3,4, Zixiang Wu1,2,3,4, Shujing Liang1,2,3,4, Zarnaz Khan1,2,3,4, Zhihao Chen1,2,3,4, Airong Qian1,2,3,4, Lifang Hu1,2,3,4.
Abstract
Piezo channels are mechanosensitive ion channels located in the cell membrane and function as key cellular mechanotransducers for converting mechanical stimuli into electrochemical signals. Emerged as key molecular detectors of mechanical forces, Piezo channels' functions in bone have attracted more and more attention. Here, we summarize the current knowledge of Piezo channels and review the research advances of Piezo channels' function in bone by highlighting Piezo1's role in bone cells, including osteocyte, bone marrow mesenchymal stem cell (BM-MSC), osteoblast, osteoclast, and chondrocyte. Moreover, the role of Piezo channels in bone diseases is summarized.Entities:
Keywords: Piezo channels; bone cells; bone disease; mechanotransduction
Year: 2021 PMID： 34208464 DOI： 10.3390/ijms22126429
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923