Muhammad Abu Tailakh1,2, Shlomo-Yaron Ishay3,4, Jenan Awesat4,5, Liat Poupko4,6, Gidon Sahar3,4, Victor Novack4,5,7. 1. Department of Nursing, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. 2. Nursing Research Unit, Soroka University Medical Center, Beer-Sheva 84101, Israel. 3. Department of Cardiothoracic Surgery, Division of Surgical Medicine, Soroka University Medical Center, Beer-Sheva 84101, Israel. 4. Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. 5. Division of Internal Medicine, Soroka University Medical Center, Beer-Sheva 84101, Israel. 6. Medical School for International Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. 7. Clinical Research Center, Soroka University Medical Center, Beer-Sheva 84101, Israel.
Abstract
OBJECTIVE: to estimate the association between preoperative hemoglobin A1c (HbA1c) levels below and above 7%, and the rate of all-cause mortality (ACM) in diabetes mellitus (DM) patients after coronary artery bypass grafting (CABG) within a ten-year follow-up period. METHODS: we collected data on patient HbA1c levels that were measured up to 3 months prior to isolated CABG in consecutive patients with DM, and analyzed the rates of ACM over a median of a 5.9-year post-operative period. RESULTS: preoperative HbA1c levels were collected in 579 DM patients. The mean HbA1c was 8.0 ± 1.7%, where 206 (35.6%) patients had an HbA1c ≤ 7% and 373 (64.4%) had an HbA1c > 7%. During the follow-up period, mortality rates were 20.4% and 28.7% in the HbA1c ≤ 7% and HbA1c > 7% groups, respectively (Kaplan-Meier estimates, log-rank p = 0.01). Multivariable Cox proportional hazards regression, adjusted for age, gender, smoking status, chronic obstructive pulmonary disease, hypertension, chronic renal failure, old myocardial infarction, number of coronary artery bypass surgeries, and post-operative glycemic control, showed a hazard ratio of 2.67 for long-term ACM (p = 0.001) in patients with HbA1c > 7%. CONCLUSIONS: DM patients with high HbA1c levels prior to CABG are at higher risk for long-term complications, especially late ACM.
OBJECTIVE: to estimate the association between preoperative hemoglobin A1c (HbA1c) levels below and above 7%, and the rate of all-cause mortality (ACM) in diabetes mellitus (DM) patients after coronary artery bypass grafting (CABG) within a ten-year follow-up period. METHODS: we collected data on patient HbA1c levels that were measured up to 3 months prior to isolated CABG in consecutive patients with DM, and analyzed the rates of ACM over a median of a 5.9-year post-operative period. RESULTS: preoperative HbA1c levels were collected in 579 DMpatients. The mean HbA1c was 8.0 ± 1.7%, where 206 (35.6%) patients had an HbA1c ≤ 7% and 373 (64.4%) had an HbA1c > 7%. During the follow-up period, mortality rates were 20.4% and 28.7% in the HbA1c ≤ 7% and HbA1c > 7% groups, respectively (Kaplan-Meier estimates, log-rank p = 0.01). Multivariable Cox proportional hazards regression, adjusted for age, gender, smoking status, chronic obstructive pulmonary disease, hypertension, chronic renal failure, old myocardial infarction, number of coronary artery bypass surgeries, and post-operative glycemic control, showed a hazard ratio of 2.67 for long-term ACM (p = 0.001) in patients with HbA1c > 7%. CONCLUSIONS:DMpatients with high HbA1c levels prior to CABG are at higher risk for long-term complications, especially late ACM.