Literature DB >> 34205102

TGF-β/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases.

Lih-Fhung Hiew1, Chi-Him Poon1, Heng-Ze You1, Lee-Wei Lim1.   

Abstract

TGF-β/Smad signalling has been the subject of extensive research due to its role in the cell cycle and carcinogenesis. Modifications to the TGF-β/Smad signalling pathway have been found to produce disparate effects on neurogenesis. We review the current research on canonical and non-canonical TGF-β/Smad signalling pathways and their functions in neurogenesis. We also examine the observed role of neurogenesis in neuropsychiatric disorders and the relationship between TGF-β/Smad signalling and neurogenesis in response to stressors. Overlapping mechanisms of cell proliferation, neurogenesis, and the development of mood disorders in response to stressors suggest that TGF-β/Smad signalling is an important regulator of stress response and is implicated in the behavioural outcomes of mood disorders.

Entities:  

Keywords:  TGF-β; depression; neurogenesis; smad; stress

Year:  2021        PMID： 34205102     DOI： 10.3390/cells10061382

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  7 in total

Review 1.  The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.

Authors:  Lili Zhang; Xiangyun Wei
Journal:  J Neurosci       Date:  2022-06-15       Impact factor: 6.709

2.  Comparative Genomics Provides Insights into Adaptive Evolution in Tactile-Foraging Birds.

Authors:  Li Wang; Li Sun; Qiu-Hong Wan; Sheng-Guo Fang
Journal:  Genes (Basel)       Date:  2022-04-12       Impact factor: 4.141

3.  Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons.

Authors:  Dahea You; Jennifer D Cohen; Olga Pustovalova; Lauren Lewis; Lei Shen
Journal:  Toxicol Sci       Date:  2022-03-28       Impact factor: 4.849

4.  Multiple Pre-Treatment miRNAs Levels in Untreated Major Depressive Disorder Patients Predict Early Response to Antidepressants and Interact with Key Pathways.

Authors:  Masaki Kato; Haruhiko Ogata; Hidetoshi Tahara; Akira Shimamoto; Yoshiteru Takekita; Yosuke Koshikawa; Keiichiro Nishida; Shinpei Nonen; Koichiro Higasa; Toshihiko Kinoshita
Journal:  Int J Mol Sci       Date:  2022-03-31       Impact factor: 5.923

5.  Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy.

Authors:  Meghan Gage; Megan Gard; Thimmasettappa Thippeswamy
Journal:  Front Cell Dev Biol       Date:  2022-03-16

6.  YAP/Smad3 promotes pathological extracellular matrix microenviroment-induced bladder smooth muscle proliferation in bladder fibrosis progression.

Authors:  Xing-Peng Di; Xi Jin; Jian-Zhong Ai; Li-Yuan Xiang; Xiao-Shuai Gao; Kai-Wen Xiao; Hong Li; De-Yi Luo; Kun-Jie Wang
Journal:  MedComm (2020)       Date:  2022-09-15

7.  Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF-β/Smad pathway.

Authors:  Ying-Li Wu; Lian-Lian Hong; Zhe-Nan Ling; Xuan-Yu Hu; Zhu Liu; Pei Li; Zhi-Qiang Ling
Journal:  J Clin Lab Anal       Date:  2022-07-23       Impact factor: 3.124
  7 in total

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