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Literature DB >> 34202839

Transcriptome and Metabolome Integrated Analysis of Two Ecotypes of Tetrastigma hemsleyanum Reveals Candidate Genes Involved in Chlorogenic Acid Accumulation.

Shuya Yin^1,2, Hairui Cui¹, Le Zhang², Jianli Yan², Lihua Qian², Songlin Ruan³.

Abstract

T. hemsleyanum plants with different geographical origins contain enormous genetic variability, which causes different composition and content of flavonoids. In this research, integrated analysis of transcriptome and metabolome were performed in two ecotypes of T. hemsleyanum. There were 5428 different expressed transcripts and 236 differentially accumulated metabolites, phenylpropane and flavonoid biosynthesis were most predominantly enriched. A regulatory network of 9 transcripts and 11 compounds up-regulated in RG was formed, and chlorogenic acid was a core component.

Entities: Chemical Disease Gene Species

Keywords: Tetrastigma hemsleyanum; chlorogenic acid; metabolome; transcriptome

Year: 2021 PMID： 34202839 DOI： 10.3390/plants10071288

Source DB: PubMed Journal: Plants (Basel) ISSN： 2223-7747

19 in total

1. Polysaccharides from Tetrastigma hemsleyanum Diels et Gilg: Extraction optimization, structural characterizations, antioxidant and antihyperlipidemic activities in hyperlipidemic mice.

Authors: Yi Ru; Xiao Chen; Jian Wang; Longhua Guo; Zhenyu Lin; Xin Peng; Bin Qiu
Journal: Int J Biol Macromol Date: 2018-11-27 Impact factor: 6.953

2. Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols.

Authors: S R Muir; G J Collins; S Robinson; S Hughes; A Bovy; C H Ric De Vos; A J van Tunen; M E Verhoeyen
Journal: Nat Biotechnol Date: 2001-05 Impact factor: 54.908

Review 3. Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity.

Authors: Michael N Clifford; Indu B Jaganath; Iziar A Ludwig; Alan Crozier
Journal: Nat Prod Rep Date: 2017-12-13 Impact factor: 13.423

4. Avoidance of antinutritive plant defense: Role of midgut pH in Colorado potato beetle.

Authors: G W Felton; J Workman; S S Duffey
Journal: J Chem Ecol Date: 1992-04 Impact factor: 2.626

5. A strategy for comprehensive identification of sequential constituents using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer, application study on chlorogenic acids in Flos Lonicerae Japonicae.

Authors: Jia-yu Zhang; Zi-jian Wang; Yun Li; Ying Liu; Wei Cai; Chen Li; Jian-qiu Lu; Yan-jiang Qiao
Journal: Talanta Date: 2015-09-16 Impact factor: 6.057

6. Both caffeoyl Coenzyme A 3-O-methyltransferase 1 and caffeic acid O-methyltransferase 1 are involved in redundant functions for lignin, flavonoids and sinapoyl malate biosynthesis in Arabidopsis.

Authors: Cao-Trung Do; Brigitte Pollet; Johanne Thévenin; Richard Sibout; Dominique Denoue; Yves Barrière; Catherine Lapierre; Lise Jouanin
Journal: Planta Date: 2007-06-27 Impact factor: 4.116

7. Antitumor activity of total flavonoids from Tetrastigma hemsleyanum Diels et Gilg is associated with the inhibition of regulatory T cells in mice.

Authors: Zhengquan Feng; Wanrong Hao; Xiaoyang Lin; Daping Fan; Juhua Zhou
Journal: Onco Targets Ther Date: 2014-06-09 Impact factor: 4.147

2. The complete chloroplast genomes of Tetrastigma hemsleyanum (Vitaceae) from different regions of China: molecular structure, comparative analysis and development of DNA barcodes for its geographical origin discrimination.

Authors: Shujie Dong; Manjia Zhou; Jinxing Zhu; Qirui Wang; Yuqing Ge; Rubin Cheng
Journal: BMC Genomics Date: 2022-08-26 Impact factor: 4.547

2 in total

Transcriptome and Metabolome Integrated Analysis of Two Ecotypes of Tetrastigma hemsleyanum Reveals Candidate Genes Involved in Chlorogenic Acid Accumulation.

1. Polysaccharides from Tetrastigma hemsleyanum Diels et Gilg: Extraction optimization, structural characterizations, antioxidant and antihyperlipidemic activities in hyperlipidemic mice.

2. Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols.

Review 3. Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity.

4. Avoidance of antinutritive plant defense: Role of midgut pH in Colorado potato beetle.

5. A strategy for comprehensive identification of sequential constituents using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer, application study on chlorogenic acids in Flos Lonicerae Japonicae.

6. Both caffeoyl Coenzyme A 3-O-methyltransferase 1 and caffeic acid O-methyltransferase 1 are involved in redundant functions for lignin, flavonoids and sinapoyl malate biosynthesis in Arabidopsis.

7. Antitumor activity of total flavonoids from Tetrastigma hemsleyanum Diels et Gilg is associated with the inhibition of regulatory T cells in mice.

8. Profiling of Altered Metabolomic States in Nicotiana tabacum Cells Induced by Priming Agents.

9. Transcriptome profiling reveals candidate flavonol-related genes of Tetrastigma hemsleyanum under cold stress.

10. Flavonoids: biosynthesis, biological functions, and biotechnological applications.

Review 1. The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review.

2. The complete chloroplast genomes of Tetrastigma hemsleyanum (Vitaceae) from different regions of China: molecular structure, comparative analysis and development of DNA barcodes for its geographical origin discrimination.