Literature DB >> 34202579

Reinvestigation of Carbohydrate Specificity of EBCA-1 Monoclonal Antibody Used for the Detection of Candida Mannan.

Vadim B Krylov1, Arsenii S Solovev1, Ilya A Puchkin1, Dmitry V Yashunsky1, Anna V Antonets1,2, Olga Y Kutsevalova3, Nikolay E Nifantiev1.   

Abstract

Monoclonal antibody EBCA-1 is used in the sandwich immune assay for the detection of circulating Candida mannan in blood sera samples for the diagnosis of invasive candidiasis. To reinvestigate carbohydrate specificity of EBCA-1, a panel of biotinylated oligosaccharides structurally related to distinct fragments of Candida mannan were loaded onto a streptavidin-coated plate to form a glycoarray. Its use demonstrated that EBCA-1 recognizes the trisaccharide β-Man-(1→2)-α-Man-(1→2)-α-Man and not homo-α-(1→2)-linked pentamannoside, as was reported previously.

Entities:  

Keywords:  candida; diagnosis; glycoarray; mannan; monoclonal antibodies

Year:  2021        PMID： 34202579     DOI： 10.3390/jof7070504

Source DB:  PubMed          Journal:  J Fungi (Basel)        ISSN： 2309-608X


  38 in total

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Journal:  Bioorg Khim       Date:  2007 Jan-Feb

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Journal:  Mycoses       Date:  2016-02-25       Impact factor: 4.377

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4.  Synthesis and molecular recognition studies of the HNK-1 trisaccharide and related oligosaccharides. The specificity of monoclonal anti-HNK-1 antibodies as assessed by surface plasmon resonance and STD NMR.

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Journal:  J Am Chem Soc       Date:  2011-12-19       Impact factor: 15.419

Review 5.  Finding the "missing 50%" of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care.

Authors:  Cornelius J Clancy; M Hong Nguyen
Journal:  Clin Infect Dis       Date:  2013-01-11       Impact factor: 9.079

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Journal:  FEMS Microbiol Lett       Date:  1998-12-01       Impact factor: 2.742

7.  Evaluation of an enzyme immunoassay using neoglycolipids constructed from Candida albicans oligomannosides to define the specificity of anti-mannan antibodies.

Authors:  C Faille; D W Mackenzie; J C Michalski; D Poulain
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-05       Impact factor: 3.267

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Authors:  Aida Pitarch; César Nombela; Concha Gil
Journal:  Curr Top Med Chem       Date:  2018       Impact factor: 3.295

9.  Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans.

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Journal:  ACS Chem Biol       Date:  2017-11-03       Impact factor: 5.100

Review 10.  Improving the diagnosis of bloodstream infections: PCR coupled with mass spectrometry.

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Journal:  Biomed Res Int       Date:  2014-04-09       Impact factor: 3.411
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  1 in total

1.  Synthesis of biotinylated pentasaccharide structurally related to a fragment of glucomannan from Candida utilis.

Authors:  D V Yashunsky; V S Dorokhova; B S Komarova; E Paulovičová; V B Krylov; N E Nifantiev
Journal:  Russ Chem Bull       Date:  2022-01-15       Impact factor: 1.222
  1 in total

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