Literature DB >> 34202521

The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes.

Ryota Inoue1, Kuniyuki Nishiyama1, Jinghe Li1, Daisuke Miyashita2, Masato Ono2, Yasuo Terauchi2, Jun Shirakawa1.   

Abstract

Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes.

Entities:  

Keywords:  diabetes; pancreatic β-cell; stem cell therapy; type 1 diabetes

Year:  2021        PMID： 34202521     DOI： 10.3390/cells10071589

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  96 in total

1.  Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells.

Authors:  Kevin A D'Amour; Anne G Bang; Susan Eliazer; Olivia G Kelly; Alan D Agulnick; Nora G Smart; Mark A Moorman; Evert Kroon; Melissa K Carpenter; Emmanuel E Baetge
Journal:  Nat Biotechnol       Date:  2006-10-19       Impact factor: 54.908

2.  Insulin degradation by acinar cell proteases creates a dysfunctional environment for human islets before/after transplantation: benefits of α-1 antitrypsin treatment.

Authors:  Gopalakrishnan Loganathan; Rajinder K Dawra; Subbiah Pugazhenthi; Zhiguang Guo; Sajjad M Soltani; Alexander Wiseman; Mark A Sanders; Klearchos K Papas; Kumaravel Velayutham; Ashok K Saluja; David E R Sutherland; Bernhard J Hering; A N Balamurugan
Journal:  Transplantation       Date:  2011-12-15       Impact factor: 4.939

Review 3.  Cost-utility analyses in diabetes: a systematic review and implications from real-world evidence.

Authors:  Yue Zhong; Pei-Jung Lin; Joshua T Cohen; Aaron N Winn; Peter J Neumann
Journal:  Value Health       Date:  2015-02-07       Impact factor: 5.725

4.  Predictive Low-Glucose Suspend Reduces Hypoglycemia in Adults, Adolescents, and Children With Type 1 Diabetes in an At-Home Randomized Crossover Study: Results of the PROLOG Trial.

Authors:  Gregory P Forlenza; Zoey Li; Bruce A Buckingham; Jordan E Pinsker; Eda Cengiz; R Paul Wadwa; Laya Ekhlaspour; Mei Mei Church; Stuart A Weinzimer; Emily Jost; Tatiana Marcal; Camille Andre; Lori Carria; Vance Swanson; John W Lum; Craig Kollman; William Woodall; Roy W Beck
Journal:  Diabetes Care       Date:  2018-08-08       Impact factor: 19.112

5.  Production of functional glucagon-secreting α-cells from human embryonic stem cells.

Authors:  Alireza Rezania; Michael J Riedel; Rhonda D Wideman; Francis Karanu; Ziliang Ao; Garth L Warnock; Timothy J Kieffer
Journal:  Diabetes       Date:  2010-10-22       Impact factor: 9.461

6.  Economic Costs of Diabetes in the U.S. in 2017.

Authors: 
Journal:  Diabetes Care       Date:  2018-03-22       Impact factor: 19.112

7.  BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells.

Authors:  Larry Sai Weng Loo; Andreas Alvin Purnomo Soetedjo; Hwee Hui Lau; Natasha Hui Jin Ng; Soumita Ghosh; Linh Nguyen; Vidhya Gomathi Krishnan; Hyungwon Choi; Xavier Roca; Shawn Hoon; Adrian Kee Keong Teo
Journal:  Cell Death Dis       Date:  2020-05-18       Impact factor: 8.469

8.  The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.

Authors:  Kevin Vivot; Valentine S Moullé; Bader Zarrouki; Caroline Tremblay; Arturo D Mancini; Hasna Maachi; Julien Ghislain; Vincent Poitout
Journal:  Mol Metab       Date:  2016-08-26       Impact factor: 7.422

Review 9.  Role of the PD-1/PD-L1 Dyad in the Maintenance of Pancreatic Immune Tolerance for Prevention of Type 1 Diabetes.

Authors:  Marika Falcone; Georgia Fousteri
Journal:  Front Endocrinol (Lausanne)       Date:  2020-08-19       Impact factor: 5.555
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  2 in total

1.  Species-dependent impact of immunosuppressive squalene-gusperimus nanoparticles and adipose-derived stem cells on isolated human and rat pancreatic islets.

Authors:  Carlos E Navarro Chica; Tian Qin; Erika Pinheiro-Machado; Bart J de Haan; M M Faas; Alexandra M Smink; Ligia Sierra; Betty L López; Paul de Vos
Journal:  Islets       Date:  2022-12-31       Impact factor: 2.308

2.  Therapeutic Effects of Insulin-Producing Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Type 1 Diabetes Mouse Model.

Authors:  Yu Mi Park; Chang Mo Yang; Hee Yeon Cho
Journal:  Int J Mol Sci       Date:  2022-06-21       Impact factor: 6.208
  2 in total

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