Literature DB >> 34201853

Numerical Simulation of Particle Dynamics in a Spiral Jet Mill via Coupled CFD-DEM.

Satyajeet Bhonsale1, Lewis Scott2, Mojtaba Ghadiri2, Jan Van Impe1.   

Abstract

Spiral jet mills are ubiquitous in the pharmaceutical industry. Breakage and classification in spiral jet mills occur due to complex interactions between the fluid and the solid phases. The study of these interactions requires the use of computational fluid dynamics (CFD) for the fluid phase coupled with discrete element models (DEM) for the particle phase. In this study, we investigate particle dynamics in a 50-mm spiral jet mill through coupled CFD-DEM simulations. The simulations showed that the fluid was significantly decelerated by the presence of the particles in the milling chamber. Furthermore, we study the particle dynamics and collision statistics at two different operating conditions and three different particle loadings. As expected, the particle velocity was affected by both the particle loading and operating pressure. The particles moved slower at low pressures and high loadings. We also found that particle-particle collisions outnumbered particle-wall collisions.

Entities:  

Keywords:  computational fluid dynamics; discrete element models; spiral jet mills

Year:  2021        PMID: 34201853     DOI: 10.3390/pharmaceutics13070937

Source DB:  PubMed          Journal:  Pharmaceutics        ISSN: 1999-4923            Impact factor:   6.321


  1 in total

Review 1.  Milling of pharmaceutical solids.

Authors:  E L Parrott
Journal:  J Pharm Sci       Date:  1974-06       Impact factor: 3.534

  1 in total
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1.  Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding.

Authors:  Laura Baraldi; Davide De Angelis; Roberto Bosi; Roberto Pennini; Irene Bassanetti; Andrea Benassi; Guido Enrico Bellazzi
Journal:  Pharmaceutics       Date:  2022-05-27       Impact factor: 6.525

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