Piotr Marcinowicz1, Magdalena Więdłocha1, Natalia Zborowska1, Weronika Dębowska1, Piotr Podwalski2, Błażej Misiak3, Ernest Tyburski4, Agata Szulc1. 1. Department of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, Poland. 2. Department of Psychiatry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland. 3. Department of Psychiatry, Wroclaw Medical University, 50-367 Wrocław, Poland. 4. Institute of Psychology, SWPS University of Social Sciences and Humanities, 03-815 Poznań, Poland.
Abstract
BACKGROUND: Cytokines have a major impact on the neurotransmitter networks that are involved in schizophrenia pathophysiology. First Episode Psychosis (FEP) patients exhibit abnormalities in cytokines levels prior to the start of treatment. Previous studies showed that antipsychotic treatment modulates cytokines levels. The aim of this meta-analysis is to further investigate this relationship. METHODS: Several online databases were searched. For meta-analysis of selected studies, we analysed variables containing the number of cases, mean and standard deviation of IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ levels before, and after, antipsychotic treatment. RESULTS: 12 studies were included in the meta-analysis. Our main results demonstrate that, in FEP patients, antipsychotic treatment is related to decreased concentrations of pro-inflammatory IL-1β, IL-6, IFN-γ, TNF-α and anti-inflammatory IL-4, IL-10 cytokines. On the other hand, levels of pro-inflammatory IL-2 and IL-17 remain unaffected. CONCLUSIONS: When compared with other meta-analyses of studies involving FEP individuals, results we obtained are consistent regarding decrease in IL-1β, IL-6. Comparing outcomes of our study with meta-analyses of schizophrenic subjects, in general, our results are consistent in IL-1β, IL-6, TNF-α, IFN-γ, IL-2. Our meta-analysis is the only one which indicates a decrease in anti-inflammatory IL-10 in FEP patients after antipsychotic treatment.
BACKGROUND: Cytokines have a major impact on the neurotransmitter networks that are involved in schizophrenia pathophysiology. First Episode Psychosis (FEP) patients exhibit abnormalities in cytokines levels prior to the start of treatment. Previous studies showed that antipsychotic treatment modulates cytokines levels. The aim of this meta-analysis is to further investigate this relationship. METHODS: Several online databases were searched. For meta-analysis of selected studies, we analysed variables containing the number of cases, mean and standard deviation of IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ levels before, and after, antipsychotic treatment. RESULTS: 12 studies were included in the meta-analysis. Our main results demonstrate that, in FEP patients, antipsychotic treatment is related to decreased concentrations of pro-inflammatory IL-1β, IL-6, IFN-γ, TNF-α and anti-inflammatory IL-4, IL-10 cytokines. On the other hand, levels of pro-inflammatory IL-2 and IL-17 remain unaffected. CONCLUSIONS: When compared with other meta-analyses of studies involving FEP individuals, results we obtained are consistent regarding decrease in IL-1β, IL-6. Comparing outcomes of our study with meta-analyses of schizophrenic subjects, in general, our results are consistent in IL-1β, IL-6, TNF-α, IFN-γ, IL-2. Our meta-analysis is the only one which indicates a decrease in anti-inflammatory IL-10 in FEP patients after antipsychotic treatment.
Entities:
Keywords:
cytokines; first episode psychosis; immune activation; psychiatry; schizophrenia
Authors: Bartosz Dawidowski; Grzegorz Grelecki; Adam Biłgorajski; Piotr Podwalski; Błażej Misiak; Jerzy Samochowiec Journal: J Clin Med Date: 2021-12-31 Impact factor: 4.241
Authors: Natalia A Shnayder; Aiperi K Khasanova; Anna I Strelnik; Mustafa Al-Zamil; Andrey P Otmakhov; Nikolay G Neznanov; German A Shipulin; Marina M Petrova; Natalia P Garganeeva; Regina F Nasyrova Journal: Int J Mol Sci Date: 2022-09-26 Impact factor: 6.208