Literature DB >> 3419861

Effects of cisapride on constipation due to a neurological lesion.

G H de Groot1, G F de Pagter.   

Abstract

Two patients with intractable constipation and an atonic bladder due to a partial spinal cord lesion and sacral nerve lesion are described. Treatment with cisapride (4 x 10 mg daily) was undertaken. After a few days the stool passed spontaneously. The effect was dose-dependent and has been maintained for at least 40 months. Normal bladder function was not achieved.

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Year:  1988        PMID: 3419861     DOI: 10.1038/sc.1988.25

Source DB:  PubMed          Journal:  Paraplegia        ISSN: 0031-1758


  3 in total

1.  Neural 5-HT4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists.

Authors:  S M Candura; E Messori; G P Franceschetti; G D'Agostino; D Vicini; M Tagliani; M Tonini
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

Review 2.  A risk-benefit assessment of cisapride in the treatment of gastrointestinal disorders.

Authors:  J Tack; G Coremans; J Janssens
Journal:  Drug Saf       Date:  1995-06       Impact factor: 5.606

Review 3.  Cisapride. An updated review of its pharmacology and therapeutic efficacy as a prokinetic agent in gastrointestinal motility disorders.

Authors:  L R Wiseman; D Faulds
Journal:  Drugs       Date:  1994-01       Impact factor: 9.546

  3 in total

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