Yuichiro Shimoyama1, Osamu Umegaki2, Noriko Kadono2, Toshiaki Minami3. 1. Department of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College Hospital, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan. shimocchiliebesfreud512@yahoo.co.jp. 2. Department of Anesthesiology, Osaka Medical College, Intensive Care Unit, Osaka Medical College Hospital, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan. 3. Department of Anesthesiology, Osaka Medical College, Osaka Medical College Hospital, Takatsuki, Osaka, 569-8686, Japan.
Abstract
OBJECTIVE: Sepsis is a major cause of mortality for critically ill patients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis. RESULTS: Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified presepsin values and Prognostic Nutritional Index as predictors of mortality in sepsis patients. Presepsin value on Day 1 was a predictor of early mortality, i.e., death within 7 days of ICU admission; ROC curve analysis revealed an AUC of 0.84, sensitivity of 89%, and specificity of 77%; and multivariate analysis showed an OR of 1.0007, with a 95%CI of 1.0001-1.0013 (p = 0.0320).
OBJECTIVE:Sepsis is a major cause of mortality for critically illpatients. This study aimed to determine whether presepsin values can predict mortality in patients with sepsis. RESULTS: Receiver operating characteristic (ROC) curve analysis, Log-rank test, and multivariate analysis identified presepsin values and Prognostic Nutritional Index as predictors of mortality in sepsispatients. Presepsin value on Day 1 was a predictor of early mortality, i.e., death within 7 days of ICU admission; ROC curve analysis revealed an AUC of 0.84, sensitivity of 89%, and specificity of 77%; and multivariate analysis showed an OR of 1.0007, with a 95%CI of 1.0001-1.0013 (p = 0.0320).
Authors: Nicolas Viallet; Vincent Brunot; Nils Kuster; Delphine Daubin; Noémie Besnard; Laura Platon; Aurèle Buzançais; Romaric Larcher; Olivier Jonquet; Kada Klouche Journal: Ann Intensive Care Date: 2016-07-22 Impact factor: 6.925