Tobias Höhne1, Christin Wenzel2, Stefan Schumann3. 1. Department of Anesthesiology and Critical Care, Medical Center-University of Freiburg, Freiburg, 79106, GERMANY. 2. Department of Anesthesiology and Critical Care, University of Freiburg Faculty of Medicine, Freiburg, GERMANY. 3. Department of Anesthesiology and Critical Care, University of Freiburg Faculty of Medicine, Freiburg im Breisgau, Baden-Württemberg, GERMANY.
Abstract
OBJECTIVE: Flow-controlled expiration (FLEX) has been shown to attenuate ventilator induced lung injury in animal models. It has also shown to homogenize compartmental pressure distribution in a physical model of the inhomogeneous respiratory system having independent compartments. We hypothesized that the homogenizing effects of FLEX are also effective in this regard when the independence of compartments is suspended by simulated chest wall compliance. APPROACH: A four compartment physical model of the respiratory system having chest wall compliance (137 ml/cmH2O) was developed. Two of the four compartments had high compliance (18 ml/cmH2O) and two had low compliance (10 ml/cmH2O). These compartments were each combined with either high (6.8 cmH2O·s/l) or low resistance (3.5 cmH2O·s/l). The model was ventilated in the volume-controlled ventilation (VCV) mode with either passive expiration or with FLEX. The maximal pressure differences (ΔPmax) and the maximal differences of mean pressure (ΔPmean) between the compartments during expiration were determined. MAIN RESULTS: With passive expiration ΔPmax reached up to 3.4 ± 0.03 cmH2O but only 0.9 ± 0.01 cmH2O with FLEX (p < 0.001). Maximal differences of ΔPmean were significantly lower with FLEX as compared to passive expiration (extending up to 0.4 ± 0.04 cmH2O vs. 2.0 ± 0.15 cmH2O, p < 0.001). SIGNIFICANCE: The homogenizing effects of FLEX on compartmental pressure distribution could be reproduced in a more complex physical model of the inhomogeneous respiratory system having chest wall compliance and might be a mechanism underlying the lung protective effects of ventilation with FLEX.
OBJECTIVE: Flow-controlled expiration (FLEX) has been shown to attenuate ventilator induced lung injury in animal models. It has also shown to homogenize compartmental pressure distribution in a physical model of the inhomogeneous respiratory system having independent compartments. We hypothesized that the homogenizing effects of FLEX are also effective in this regard when the independence of compartments is suspended by simulated chest wall compliance. APPROACH: A four compartment physical model of the respiratory system having chest wall compliance (137 ml/cmH2O) was developed. Two of the four compartments had high compliance (18 ml/cmH2O) and two had low compliance (10 ml/cmH2O). These compartments were each combined with either high (6.8 cmH2O·s/l) or low resistance (3.5 cmH2O·s/l). The model was ventilated in the volume-controlled ventilation (VCV) mode with either passive expiration or with FLEX. The maximal pressure differences (ΔPmax) and the maximal differences of mean pressure (ΔPmean) between the compartments during expiration were determined. MAIN RESULTS: With passive expiration ΔPmax reached up to 3.4 ± 0.03 cmH2O but only 0.9 ± 0.01 cmH2O with FLEX (p < 0.001). Maximal differences of ΔPmean were significantly lower with FLEX as compared to passive expiration (extending up to 0.4 ± 0.04 cmH2O vs. 2.0 ± 0.15 cmH2O, p < 0.001). SIGNIFICANCE: The homogenizing effects of FLEX on compartmental pressure distribution could be reproduced in a more complex physical model of the inhomogeneous respiratory system having chest wall compliance and might be a mechanism underlying the lung protective effects of ventilation with FLEX.