| Literature DB >> 34192537 |
Julian Susat1, Harald Lübke2, Alexander Immel1, Ute Brinker2, Aija Macāne3, John Meadows4, Britta Steer5, Andreas Tholey5, Ilga Zagorska6, Guntis Gerhards6, Ulrich Schmölcke2, Mārcis Kalniņš6, Andre Franke1, Elīna Pētersone-Gordina6, Barbara Teßman7, Mari Tõrv8, Stefan Schreiber9, Christian Andree10, Valdis Bērziņš6, Almut Nebel1, Ben Krause-Kyora11.
Abstract
A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300-5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039 are consistent with the hypothesis that this very early Y. pestis form was most likely less transmissible and maybe even less virulent than later strains. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline. The geographical and temporal distribution of the few prehistoric Y. pestis cases reported so far is more in agreement with single zoonotic events.Entities:
Keywords: Yersinia pestis; aDNA; hunter-gatherer; zoonosis
Mesh：
Year: 2021 PMID： 34192537 DOI： 10.1016/j.celrep.2021.109278
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423