Hui Wang1, Wen Yang1, Jinnan Liu1, Junhong Leng2, Weiqin Li2, Zhijie Yu3,4, Jing Li1,5,6, Ronald C W Ma7,8, Gang Hu9, Zhongze Fang5,6,10, Ying Wang11,12, Xilin Yang1,5,6. 1. Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. 2. Project Office, Tianjin Women and Children's Health Center, Tianjin, China. 3. Population Cancer Research Program, Dalhousie University, Halifax, Nova Scotia, Canada. 4. Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. 5. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. 6. Tianjin Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China. 7. Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. 8. Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. 9. Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA. 10. Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China. 11. Scientific Research Platform of the Second School of Clinical Medicine, Guangdong Medical University, Dongguan, Guangdong, China. 12. Key Laboratory of 3D Printing Technology in Stomatology, Guangdong Medical University, Dongguan, Guangdong, China.
Abstract
BACKGROUND: Interactions between genetic and nutritional factors can contribute to the risk of gestational diabetes mellitus (GDM). OBJECTIVES: We aimed to explore the associations of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 (CDKAL1) single-nucleotide polymorphism (SNP) rs7747752 and serum concentrations of SFAs with the risk of GDM in Chinese women. METHODS: We conducted a 1:1 case-control study in a prospective cohort of pregnant women in Tianjin, China. Serum SFA data were collected from a total of 243 women with GDM and their controls matched by maternal age (±1 y). Among them, 207 case-control pairs had high-quality sequencing data. P/L and S/P ratios were defined as palmitic acid (16:0)/lauric acid (12:0) and stearic acid (18:0)/palmitic acid, respectively. Conditional logistic regression analysis was performed to estimate associations of CDKAL1 SNP rs7747752 and serum concentrations of SFAs with the risk of GDM. An additive interaction between rs7747752 and palmitic acid was analyzed to test the contribution of their interaction to the risk of GDM. RESULTS: Among the 5 tested SFAs, palmitic acid was positively whereas lauric acid was negatively associated with the risk of GDM. A P/L ratio ≥12.2 and an S/P ratio ≤0.71 were independently and synergistically associated with an increased risk of GDM. The CDKAL1 rs7747752 G > C variant was significantly associated with an increased risk of GDM (P < 0.05). Furthermore, the presence of the rs7747752 G > C variant increased the OR (95% CI) of high palmitic acid concentration from 1.55 (0.61, 3.97) to 4.34 (2.04, 9.23), with a significant additive interaction. CONCLUSIONS: The interaction between high serum palmitic acid concentration and the CDKAL1 rs7747752 G > C variant played a critical role in GDM. Given that a hypocaloric low-carbohydrate diet can lower palmitic acid concentrations, it is worthwhile to test whether such a diet is effective in reducing the risk of GDM, especially among women who have both risk factors.
BACKGROUND: Interactions between genetic and nutritional factors can contribute to the risk of gestational diabetes mellitus (GDM). OBJECTIVES: We aimed to explore the associations of cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 (CDKAL1) single-nucleotide polymorphism (SNP) rs7747752 and serum concentrations of SFAs with the risk of GDM in Chinese women. METHODS: We conducted a 1:1 case-control study in a prospective cohort of pregnant women in Tianjin, China. Serum SFA data were collected from a total of 243 women with GDM and their controls matched by maternal age (±1 y). Among them, 207 case-control pairs had high-quality sequencing data. P/L and S/P ratios were defined as palmitic acid (16:0)/lauric acid (12:0) and stearic acid (18:0)/palmitic acid, respectively. Conditional logistic regression analysis was performed to estimate associations of CDKAL1 SNP rs7747752 and serum concentrations of SFAs with the risk of GDM. An additive interaction between rs7747752 and palmitic acid was analyzed to test the contribution of their interaction to the risk of GDM. RESULTS: Among the 5 tested SFAs, palmitic acid was positively whereas lauric acid was negatively associated with the risk of GDM. A P/L ratio ≥12.2 and an S/P ratio ≤0.71 were independently and synergistically associated with an increased risk of GDM. The CDKAL1rs7747752 G > C variant was significantly associated with an increased risk of GDM (P < 0.05). Furthermore, the presence of the rs7747752 G > C variant increased the OR (95% CI) of high palmitic acid concentration from 1.55 (0.61, 3.97) to 4.34 (2.04, 9.23), with a significant additive interaction. CONCLUSIONS: The interaction between high serum palmitic acid concentration and the CDKAL1rs7747752 G > C variant played a critical role in GDM. Given that a hypocaloric low-carbohydrate diet can lower palmitic acid concentrations, it is worthwhile to test whether such a diet is effective in reducing the risk of GDM, especially among women who have both risk factors.
Authors: Mariana Alves; Marília Andreia Fernandes; Gülistan Bahat; Athanase Benetos; Hugo Clemente; Tomasz Grodzicki; Manuel Martínez-Sellés; Francesco Mattace-Raso; Chakravarthi Rajkumar; Andrea Ungar; Nikos Werner; Timo E Strandberg Journal: Eur Geriatr Med Date: 2021-05-25 Impact factor: 1.710