| Literature DB >> 3419202 |
Abstract
A fraction from an alcoholic extract of Sida veronicaefolia, previously reported to be a potent oxytocic, was studied for its abortifacient effects in pregnant rats. Oral doses producing the abortifacient effects were greater than or equal to 32 ml/kg when administered from the 15th-17th day of pregnancy. Similar effects were produced by intravenous doses of greater than or equal to 3 ml/kg. At the minimum effective oral dose of 32 ml/kg, those animals that carried the conceptuses to term (40%) had litters with reduced average number/litter and weight. At twice this dose, only 10% delivered and the litters were sickly. The effects of intravenous administration of the extract was similar but more pronounced and included also some unique acute effects.Entities:
Keywords: Abortifacient Agents--administraction and dosage; Abortifacient Agents--side effects; Abortion, Drug Induced; Abortion, Induced; Africa; Africa South Of The Sahara; Animals, Laboratory; Biology; Body Weight--changes; Clinical Research; Control Groups; Delivery Of Health Care; Developing Countries; English Speaking Africa; Examinations And Diagnoses; Family Planning; Fertility Control, Postconception; Ghana; Health; Health Services; Laboratory Examinations And Diagnoses; Medicine; Physiology; Plants, Medicinal; Research Methodology; Western Africa
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Year: 1988 PMID： 3419202 DOI： 10.1016/0378-8741(88)90112-2
Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360