| Literature DB >> 34190968 |
Alexandra M Zaborowski1, Ahmed Abdile2, Michel Adamina3, Felix Aigner4, Laura d'Allens3, Caterina Allmer4, Andrea Álvarez5, Rocio Anula6, Mihailo Andric7, Sam Atallah8, Simon Bach9, Miklosh Bala10, Marie Barussaud11, Augustinas Bausys12, Brendan Bebington13, Andrew Beggs9, Felipe Bellolio14, Melissa-Rose Bennett15, Anton Berdinskikh16, Vicki Bevan17, Sebastiano Biondo5, Gabriele Bislenghi18, Marc Bludau19, Adam Boutall20, Nelleke Brouwer21, Carl Brown22, Christiane Bruns19, Daniel D Buchanan23, Pamela Buchwald24, Jacobus W A Burger25, Nikita Burlov26, Michela Campanelli27, Maylis Capdepont28, Michele Carvello29, Hwee-Hoon Chew30, Dimitri Christoforidis31, David Clark32, Marta Climent5, Kyle G Cologne33, Tomas Contreras34, Roland Croner7, Ian R Daniels15, Giovanni Dapri35, Justin Davies36, Paolo Delrio37, Quentin Denost28, Michael Deutsch38, Andre Dias39, André D'Hoore18, Evgeniy Drozdov40, Daniel Duek41, Malcolm Dunlop42, Adam Dziki43, Aleksandra Edmundson32, Sergey Efetov44, Alaa El-Hussuna45, Brodie Elliot46, Sameh Emile47, Eloy Espin48, Martyn Evans17, Seraina Faes49, Omar Faiz50, Fergal Fleming51, Caterina Foppa29, George Fowler15, Matteo Frasson52, Nuno Figueiredo53, Tim Forgan54, Frank Frizelle55, Shamil Gadaev56, Jose Gellona57,58, Tamara Glyn55, Jianping Gong59, Barisic Goran60, Emma Greenwood61, Marianne G Guren62, Stephanie Guillon28, Ida Gutlic24, Dieter Hahnloser49, Heather Hampel63, Ann Hanly1, Hirotoshi Hasegawa64, Lene Hjerrild Iversen65, Andrew Hill2, James Hill66, Jiri Hoch67, Michael Hoffmeister68, Roel Hompes69, Luis Hurtado52, Fabiano Iaquinandi31, Ugne Imbrasaite70, Rumana Islam71, Mehrenah Dorna Jafari72, Yukihide Kanemitsu73, Aleksei Karachun74, Ahmer A Karimuddin75, Deborah S Keller76, Justin Kelly77, Rory Kennelly1, Gleb Khrykov26, Peter Kocian67, Cherry Koh78, Neils Kok79, Katrina A Knight80, Joep Knol81, Christos Kontovounisios82, Hartwig Korner83, Zoran Krivokapic60, Irmgard Kronberger84, Hidde Maarten Kroon85, Marius Kryzauskas70, Said Kural86, Miranda Kusters87, Zaher Lakkis88, Timur Lankov74, Dave Larson89, György Lázár90, Kai-Yin Lee30, Suk Hwan Lee91, Jérémie H Lefèvre92, Anna Lepisto93, Christopher Lieu94, Lynette Loi80, Craig Lynch95, Helene Maillou-Martinaud28, Annalisa Maroli29, Sean Martin1, Anna Martling96, Klaus E Matzel97, Julio Mayol6, Frank McDermott15, Guillaume Meurette98, Monica Millan99, Martin Mitteregger4, Andrei Moiseenko74, John R T Monson100, Stefan Morarasu1, Konosuke Moritani73, Gabriela Möslein101, Martino Munini31, Caio Nahas39, Sergio Nahas39, Ionut Negoi102, Anastasia Novikova103, Misael Ocares104, Koji Okabayashi105, Alexandra Olkina74, Luis Oñate-Ocaña106, Jaime Otero6, Cihan Ozen45, Ugo Pace37, Guilherme Pagin São Julião107, Lidiia Panaiotti74, Yves Panis108, Demetris Papamichael109, Jason Park110, Swati Patel111, Juan Carlos Patrón Uriburu112, Miguel Pera113, Rodrigo O Perez114, Alexei Petrov74, Frank Pfeffer115, P Terry Phang75, Tomas Poskus116, Heather Pringle15, David Proud71, Ivana Raguz117, Nuno Rama118, Shahnawaz Rasheed82, Manoj J Raval75, Daniela Rega37, Christoph Reissfelder119, Juan Carlos Reyes Meneses120, Frederic Ris121, Stefan Riss122, Homero Rodriguez-Zentner123, Campbell S Roxburgh124, Avanish Saklani125, Andrea Jiménez Salido113, Tarik Sammour85, Deborah Saraste126, Martin Schneider127, Ryo Seishima105, Aleksandar Sekulic60, Toni Seppala93, Kieran Sheahan1, Rebecca Shine71, Alexandra Shlomina44, Guiseppe S Sica27, Tongplaew Singnomklao96, Leandro Siragusa27, Neil Smart15, Alejandro Solis48, Antonino Spinelli128, Roxane D Staiger117, Michael J Stamos72, Scott Steele129, Michael Sunderland46, Ker-Kan Tan130, Pieter J Tanis131, Paris Tekkis82, Biniam Teklay132, Sabrina Tengku80, Marta Jiménez-Toscano113, Petr Tsarkov44, Matthias Turina117, Alexis Ulrich133, Bruna B Vailati107, Meike van Harten61, Cornelis Verhoef134, Satish Warrier135, Steve Wexner136, Hans de Wilt21, Benjamin A Weinberg137, Cameron Wells138, Albert Wolthuis18, Evangelos Xynos139, Nancy You140, Alexander Zakharenko103, Justino Zeballos141, Des C Winter1.
Abstract
Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are unclear. It appears to represent a unique disease process with different clinical, pathological, and molecular characteristics compared with late-onset colorectal cancer. Data on oncological outcomes are limited, and sensitivity to conventional neoadjuvant and adjuvant therapy regimens appear to be unknown. The purpose of this review is to summarize the available literature on early-onset colorectal cancer. Observations: Within the next decade, it is estimated that 1 in 10 colon cancers and 1 in 4 rectal cancers will be diagnosed in adults younger than 50 years. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Although genetic predisposition plays a role, most cases are sporadic. The full spectrum of germline and somatic sequence variations implicated remains unknown. Younger patients typically present with descending colonic or rectal cancer, advanced disease stage, and unfavorable histopathological features. Despite being more likely to receive neoadjuvant and adjuvant therapy, patients with early-onset disease demonstrate comparable oncological outcomes with their older counterparts. Conclusions and Relevance: The clinicopathological features, underlying molecular profiles, and drivers of early-onset colorectal cancer differ from those of late-onset disease. Standardized, age-specific preventive, screening, diagnostic, and therapeutic strategies are required to optimize outcomes.Entities:
Mesh：
Year: 2021 PMID： 34190968 DOI： 10.1001/jamasurg.2021.2380
Source DB: PubMed Journal: JAMA Surg ISSN： 2168-6254 Impact factor: 14.766