| Literature DB >> 34189650 |
O N Solopova1, Yu P Finashutina2,3, N N Kasatkina2, N A Lyzhko2,3, A A Turba2, L A Kesaeva2,3, V A Misyurin2,3, A V Misyurin3, M V Larina4, T K Aliev4,5, M P Kirpichnikov4,5.
Abstract
Two monoclonal antibodies recognizing non-overlapping epitopes of the PRAME protein were injected into immunocompetent mice to study their influence on the growth of subcutaneous tumor nodes. The B16F10 murine melanoma line, either expressing human PRAME protein or bearing only a vector without PRAME gene, were used as transplants. Each of the antibodies showed the ability to suppress tumor growth of a PRAME-expressing tumour, but not a tumor without PRAME.Entities:
Keywords: PRAME; cancer testis antigen; monoclonal antibodies
Year: 2021 PMID： 34189650 DOI： 10.1134/S1607672921030091
Source DB: PubMed Journal: Dokl Biochem Biophys ISSN： 1607-6729 Impact factor: 0.788