Hidayet Ece Arat Çelik1,2, Deniz Ceylan3, Ceren Hidiroğlu Ongun4, Ayşe Erdoğan2, Devran Tan5, Peren Gümüşkesen2, Başak Bağci6, Ayşegül Özerdem7. 1. Maltepe University, Faculty of Medicine, Department of Psychiatry, İstanbul, Turkey. 2. Dokuz Eylül University, Institute of Health Sciences, Department of Neuroscience, İzmir, Turkey. 3. Koç University, Faculty of Medicine, Department of Psychiatry, İstanbul, Turkey. 4. Dokuz Eylül University, Faculty of Arts, Department of Psychology, İzmir, Turkey. 5. Nişantaşı University, Faculty of Economics, Administrative and Scocial Sciences, Department of Psychology, İstanbul, Turkey. 6. Katip Çelebi University, Ataturk Training and Research Hospital, Department of Psychiatry, İzmir, Turkey. 7. Mayo Clinic, Department of Psychiatry and Psychology, Rochester, MN, USA.
Abstract
INTRODUCTION: Bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) often co-occur in adult population. Both conditions present various neurocognitive and behavioral problems. We aimed to examine neurocognitive functions in adult patients with comorbid BD and ADHD (BD+ADHD) in comparison to patients with only BD, only ADHD and healthy controls (HCs). METHOD: An extensive cognitive battery which evaluates verbal learning and memory, visual memory, processing speed, attention, executive functions, working memory and verbal fluency, was used to assess neurocognitive functions respectively in adult (age 18-65 years) patients with BD (n=37), ADHD (n=43), BD+ADHD (n=20) in comparison to HCs (n=51). The Multivariate Analysis of Covariance models, where age, level of education and total BIS-11 scores were included as covariates, were used for comparing neurocognitive scores among groups. RESULTS: Both BD and BD+ADHD groups showed significantly poorer performance than HCs in processing speed, attention, executive functions, and verbal fluency domains. The BD group had additional significant deficits in executive functions, verbal learning and memory domains. There were no significant differences between BD and BD+ADHD groups with regards to verbal learning and memory, visual memory, processing speed, attention, executive functions, working memory and verbal fluency domains. Patients with only ADHD showed significantly poorer performance than HCs in verbal fluency domain. CONCLUSIONS: Our results show similarities in the neurocognitive functions of adults with BD and BD+ADHD across a wide range of cognitive domains. The findings point to the need for further exploration of diverging and converging neurodevelopmental trajectories of BD and ADHD. Copyright:
INTRODUCTION: Bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) often co-occur in adult population. Both conditions present various neurocognitive and behavioral problems. We aimed to examine neurocognitive functions in adult patients with comorbid BD and ADHD (BD+ADHD) in comparison to patients with only BD, only ADHD and healthy controls (HCs). METHOD: An extensive cognitive battery which evaluates verbal learning and memory, visual memory, processing speed, attention, executive functions, working memory and verbal fluency, was used to assess neurocognitive functions respectively in adult (age 18-65 years) patients with BD (n=37), ADHD (n=43), BD+ADHD (n=20) in comparison to HCs (n=51). The Multivariate Analysis of Covariance models, where age, level of education and total BIS-11 scores were included as covariates, were used for comparing neurocognitive scores among groups. RESULTS: Both BD and BD+ADHD groups showed significantly poorer performance than HCs in processing speed, attention, executive functions, and verbal fluency domains. The BD group had additional significant deficits in executive functions, verbal learning and memory domains. There were no significant differences between BD and BD+ADHD groups with regards to verbal learning and memory, visual memory, processing speed, attention, executive functions, working memory and verbal fluency domains. Patients with only ADHD showed significantly poorer performance than HCs in verbal fluency domain. CONCLUSIONS: Our results show similarities in the neurocognitive functions of adults with BD and BD+ADHD across a wide range of cognitive domains. The findings point to the need for further exploration of diverging and converging neurodevelopmental trajectories of BD and ADHD. Copyright:
Authors: Alison K Merikangas; Lihong Cui; Monica E Calkins; Tyler M Moore; Ruben C Gur; Raquel E Gur; Kathleen R Merikangas Journal: J Affect Disord Date: 2017-03-10 Impact factor: 4.839
Authors: Imma Torres; Marina Garriga; Brisa Sole; Caterina M Bonnín; Montse Corrales; Esther Jiménez; Eva Sole; Josep A Ramos-Quiroga; Eduard Vieta; Jose M Goikolea; Anabel Martínez-Aran Journal: J Affect Disord Date: 2017-09-25 Impact factor: 4.839