Literature DB >> 34187612

Story Memory Impairment Rates and Association with Hippocampal Volumes in a Memory Clinic Population.

Christina G Wong1, Sharlene L Jeffers1, Samantha A Bell1, Jessica Z K Caldwell1, Sarah J Banks2, Justin B Miller1.   

Abstract

OBJECTIVE: Story memory tasks are among the most commonly used memory tests; however, research suggests they may be less sensitive to memory decline and have a weaker association with hippocampal volumes than list learning tasks. To examine its utility, we compared story memory to other memory tests on impairment rates and association with hippocampal volumes.
METHOD: Archival records from 1617 older adults (Mage = 74.41, range = 65-93) who completed the Wechsler Memory Scale - 4th edition (WMS-IV) Logical Memory (LM), Hopkins Verbal Learning Test - Revised (HVLT-R), and Brief Visuospatial Memory Test - Revised (BVMT-R) as part of a clinical neuropsychological evaluation were reviewed. Scores >1.5 SD below age-adjusted means were considered impaired, and frequency distributions were used to examine impairment rates. A subset of participants (n = 179) had magnetic resonance imaging (MRI) data that underwent image quality assessment. Partial correlations and linear regression analyses, accounting for age, education, and total intracranial volume (TIV), examined associations between memory raw scores and hippocampal volumes.
RESULTS: For delayed recall, nearly half of the sample was impaired on HVLT-R (48.8%) and BVMT-R (46.1%), whereas a little more than a third was impaired on LM (35.7%). Better performance on all three measures was related to larger hippocampal volumes (r's =. 26-.43, p's < .001). Individually adding memory scores to regression models predicting hippocampal volumes improved the model fit for all measures.
CONCLUSIONS: Despite findings suggesting that story memory is less sensitive to memory dysfunction, it was not differentially associated with hippocampal volumes compared to other memory measures. Results support assessing memory using different formats and modalities in older adults.

Entities:  

Keywords:  Aged; Alzheimer disease; Hippocampus; Magnetic resonance imaging; Memory disorders; Neuropsychological tests

Mesh:

Year:  2021        PMID: 34187612      PMCID: PMC8716676          DOI: 10.1017/S1355617721000850

Source DB:  PubMed          Journal:  J Int Neuropsychol Soc        ISSN: 1355-6177            Impact factor:   3.114


  39 in total

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4.  A nonparametric method for automatic correction of intensity nonuniformity in MRI data.

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Review 8.  Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: review and meta-analysis.

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Journal:  J Neurosci       Date:  2004-01-28       Impact factor: 6.167

10.  Verbal and non-verbal memory and hippocampal volumes in a memory clinic population.

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