Literature DB >> 34185537

Synergy in Nanomedicine: What It Is Not, and What It Might Be.

Steven J Staffa1, Daniel S Kohane1, David Zurakowski1.   

Abstract

Interactions between nanoformulations delivering two or more drugs-or a drug and some other therapeutic modality-are often described as synergistic. In fact, synergy is a specific term of art, with important therapeutic implications. The term is often misused in the nanoscience literature. Here we discuss what synergy is and an approach to demonstrating it rigorously.

Entities:  

Keywords:  additivity; antagonism; combination index; isobologram; synergy

Mesh：

Year:  2021        PMID： 34185537      PMCID： PMC8950954          DOI： 10.1021/acs.nanolett.1c01894

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  13 in total

1.  Isobolographic analysis for combinations of a full and partial agonist: curved isoboles.

Authors:  Yury Grabovsky; Ronald J Tallarida
Journal:  J Pharmacol Exp Ther       Date:  2004-06-02       Impact factor: 4.030

Review 2.  Revisiting the isobole and related quantitative methods for assessing drug synergism.

Authors:  Ronald J Tallarida
Journal:  J Pharmacol Exp Ther       Date:  2012-04-17       Impact factor: 4.030

Review 3.  Nanoparticle-based combination therapy toward overcoming drug resistance in cancer.

Authors:  Che-Ming Jack Hu; Liangfang Zhang
Journal:  Biochem Pharmacol       Date:  2012-01-18       Impact factor: 5.858

Review 4.  Nanoparticle-Based Combination Therapy for Cancer Treatment.

Authors:  Ji Young Yhee; Sejin Son; Hyukjin Lee; Kwangmeyung Kim
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

Review 5.  Understanding synergy.

Authors:  Nori Geary
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-12-04       Impact factor: 4.310

Review 6.  Synergy, additivism and antagonism in immunosuppression. A critical review.

Authors:  M C Berenbaum
Journal:  Clin Exp Immunol       Date:  1977-04       Impact factor: 4.330

Review 7.  Recent advances in functional mesoporous silica-based nanoplatforms for combinational photo-chemotherapy of cancer.

Authors:  Yin-Jia Cheng; Jing-Jing Hu; Si-Yong Qin; Ai-Qing Zhang; Xian-Zheng Zhang
Journal:  Biomaterials       Date:  2019-12-27       Impact factor: 12.479

Review 8.  An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines.

Authors:  Kyle R Roell; David M Reif; Alison A Motsinger-Reif
Journal:  Front Pharmacol       Date:  2017-04-20       Impact factor: 5.810

9.  Additive Dose Response Models: Defining Synergy.

Authors:  Simone Lederer; Tjeerd M H Dijkstra; Tom Heskes
Journal:  Front Pharmacol       Date:  2019-11-26       Impact factor: 5.810

Review 10.  Analysis of drug combinations: current methodological landscape.

Authors:  Julie Foucquier; Mickael Guedj
Journal:  Pharmacol Res Perspect       Date:  2015-05-20
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  1 in total

1.  Simultaneous Exposure of Different Nanoparticles Influences Cell Uptake.

Authors:  Isa de Boer; Ceri J Richards; Christoffer Åberg
Journal:  Pharmaceutics       Date:  2022-01-06       Impact factor: 6.321
  1 in total

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