Ivan Vollmer1,2, Nuria Sánchez-Izquierdo3, Daniel Martínez2,4, David Sánchez-Lorente2,5, Sebastián Casanueva-Eliceiry3, Marc Boada5, Ángela Guirao5, Inmaculada Romero-Zayas3, Sergi Vidal-Sicart3,6, Pilar Paredes7,8,9. 1. Radiology Department, Hospital Clínic Barcelona, Barcelona, Spain. 2. Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain. 3. Nuclear Medicine Department, Hospital Clínic Barcelona, Barcelona, Spain. 4. Pathology Department, Hospital Clínic Barcelona, Barcelona, Spain. 5. Thoracic Surgery Department, Hospital Clínic Barcelona, Barcelona, Spain. 6. Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Villarroel 170, 08036, Barcelona, Spain. 7. Faculty of Medicine, University of Barcelona (UB), Barcelona, Spain. pparedes@clinic.cat. 8. Nuclear Medicine Department, Hospital Clínic Barcelona, Barcelona, Spain. pparedes@clinic.cat. 9. Institut D'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Villarroel 170, 08036, Barcelona, Spain. pparedes@clinic.cat.
Abstract
PURPOSE: Radioguided occult lesion localization (ROLL) of pulmonary nodules is an alternative to hook-wire. Both required of a histological margin assessment. The activity emerging from the radiotracer allows to obtain an intraoperative scintigraphic image of the surgical specimen by a portable gamma-camera (PGC) fitted with an optical view, which provides information about the localization of the nodule in relation to the margins. The aim of this study was to evaluate the intraoperative use of a PGC for margin assessment of pulmonary nodules. METHODS: ROLL technique was used in 38 nodules (36 pulmonary, 1 chest wall, and 1 pleural nodules). A PGC intraoperative image of the surgical specimen was obtained in 32. Scintigraphic results were compared to the histological assessment. Other factors, such as nodule size, distance from the pleural surface, or distance covered by the needle, were considered as possible factors for non-centered lesions. RESULTS: PGC images showed that the lesion was in contact with the margins in 8/32 cases and centered in 24. In all cases in which the lesion was considered as centered by the PGC, the margins were free of involvement (NPV 100%), although the PPV is low. CONCLUSIONS: The use of a PGC for margin assessment after pulmonary nodule resection is feasible and provides a high NPV in our series. In addition, the short intraoperative time required for its use makes the PGC a useful tool for providing supplementary information to histopathologic results. Further studies from different surgical teams are required for an external validation.
PURPOSE: Radioguided occult lesion localization (ROLL) of pulmonary nodules is an alternative to hook-wire. Both required of a histological margin assessment. The activity emerging from the radiotracer allows to obtain an intraoperative scintigraphic image of the surgical specimen by a portable gamma-camera (PGC) fitted with an optical view, which provides information about the localization of the nodule in relation to the margins. The aim of this study was to evaluate the intraoperative use of a PGC for margin assessment of pulmonary nodules. METHODS: ROLL technique was used in 38 nodules (36 pulmonary, 1 chest wall, and 1 pleural nodules). A PGC intraoperative image of the surgical specimen was obtained in 32. Scintigraphic results were compared to the histological assessment. Other factors, such as nodule size, distance from the pleural surface, or distance covered by the needle, were considered as possible factors for non-centered lesions. RESULTS: PGC images showed that the lesion was in contact with the margins in 8/32 cases and centered in 24. In all cases in which the lesion was considered as centered by the PGC, the margins were free of involvement (NPV 100%), although the PPV is low. CONCLUSIONS: The use of a PGC for margin assessment after pulmonary nodule resection is feasible and provides a high NPV in our series. In addition, the short intraoperative time required for its use makes the PGC a useful tool for providing supplementary information to histopathologic results. Further studies from different surgical teams are required for an external validation.
Authors: Shaunagh McDermott; Florian J Fintelmann; Andrew J Bierhals; Douglas D Silin; Melissa C Price; Harald C Ott; Jo-Anne O Shepard; John R Mayo; Amita Sharma Journal: Radiographics Date: 2019-08-16 Impact factor: 5.333
Authors: A Chella; M Lucchi; M C Ambrogi; G Menconi; F M Melfi; A Gonfiotti; G Boni; C A Angeletti Journal: Eur J Cardiothorac Surg Date: 2000-07 Impact factor: 4.191