Asbjørn Støylen1,2, Annichen Søyland Daae1,2. 1. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. 2. Department of Cardiology, St. Olav Hospital/Trondheim University Hospital, Trondheim, Norway.
Abstract
BACKGROUND: Tissue Doppler shows short duration velocity spikes during pre- and post-ejection (protodiastole). They have been assumed to be isovolumic contraction and relaxation movements, but this is not in accordance with newer studies. METHODS: We examined 22 healthy volunteers. Valve closures and openings were determined from spectral Doppler from LVOT and mitral inflow and transferred to colour tissue Doppler recordings for comparison with tissue velocities, colour M-mode and strain rate (SR). RESULTS: Pre-ejection positive velocity spikes were simultaneous in both walls, starting ca. 24.8 ± 10.1 ms after start QRS, duration 51.5 ± 10.8 ms, ending 10.2 ± 11.5 ms after mitral valve closure (MVC) (p < 0.001). There were corresponding colour tracings and negative strain rate. Protodiastolic lengthening was predominant in the septum. Negative velocity spikes had a duration of 35.5 ± 10.7 ms, ending 9.5 ± 14.7 ms after aortic valve closure (AVC, p < 0.001) in septum. During isovolumic relaxation, strain rate showed apical lengthening (Peak SR-0.72 ± 0.50 s-1 ) and basal shortening (Peak SR 0.44 ± 0.63 s-1 ). CONCLUSION: Electromechanical activation of the LV is simultaneous in septum and lateral wall, occurs before MVC, is terminated by MVC itself and is thus not isovolumic. Protodiastole is a short event of lengthening, predominantly in the septum. It may be the mechanism for valve closure and ends by AVC itself. Isovolumic relaxation occurs after this velocity spike, and is characterized by elongation of the apex, shortening of the base, thus showing a volume shift from base towards apex.
BACKGROUND: Tissue Doppler shows short duration velocity spikes during pre- and post-ejection (protodiastole). They have been assumed to be isovolumic contraction and relaxation movements, but this is not in accordance with newer studies. METHODS: We examined 22 healthy volunteers. Valve closures and openings were determined from spectral Doppler from LVOT and mitral inflow and transferred to colour tissue Doppler recordings for comparison with tissue velocities, colour M-mode and strain rate (SR). RESULTS: Pre-ejection positive velocity spikes were simultaneous in both walls, starting ca. 24.8 ± 10.1 ms after start QRS, duration 51.5 ± 10.8 ms, ending 10.2 ± 11.5 ms after mitral valve closure (MVC) (p < 0.001). There were corresponding colour tracings and negative strain rate. Protodiastolic lengthening was predominant in the septum. Negative velocity spikes had a duration of 35.5 ± 10.7 ms, ending 9.5 ± 14.7 ms after aortic valve closure (AVC, p < 0.001) in septum. During isovolumic relaxation, strain rate showed apical lengthening (Peak SR-0.72 ± 0.50 s-1 ) and basal shortening (Peak SR 0.44 ± 0.63 s-1 ). CONCLUSION: Electromechanical activation of the LV is simultaneous in septum and lateral wall, occurs before MVC, is terminated by MVC itself and is thus not isovolumic. Protodiastole is a short event of lengthening, predominantly in the septum. It may be the mechanism for valve closure and ends by AVC itself. Isovolumic relaxation occurs after this velocity spike, and is characterized by elongation of the apex, shortening of the base, thus showing a volume shift from base towards apex.
Authors: A Hagendorff; A Helfen; R Brandt; E Altiok; O Breithardt; D Haghi; J Knierim; D Lavall; N Merke; C Sinning; S Stöbe; C Tschöpe; F Knebel; S Ewen Journal: Clin Res Cardiol Date: 2022-06-04 Impact factor: 5.460
Authors: Alaa Mabrouk Salem Omar; Diana Maria Ronderos Botero; Javier Arreaza Caraballo; Ga Hee Kim; Yeraz Khachatoorian; Jaclyn Kliewer; Mohamed Ahmed Abdel Rahman; Osama Rifaie; Jonathan N Bella; Edgar Argulian; Johanna Contreras Journal: Cardiovasc Ultrasound Date: 2022-07-14 Impact factor: 2.263