Jinju Dong1, Shouyan Liu2, Lingyun Wang3, Xingjian Zhou1, Qinghong Zhou1, Congli Liu1, Jingrui Zhu2, Weilan Yuan3, Wang-Yang Xu4, Jie Deng5. 1. Department of Gynaecology and Obstetrics, Xiangyang No.1 People's Hospital, Hubei University of Medcine, Xiangyang, 441000, China. 2. Department of Obstetrics, Pingdingshan No.1 People's Hospital, Pingdingshan, 467000, China. 3. Biotecan Medical Diagnostics Co., Ltd, Zhangjiang Center for Translational Medicine, Shanghai, 201204, China. 4. Singlera Genomics (Shanghai) Ltd, Shanghai, 201318, China. Rita_xwy@126.com. 5. Department of Gynaecology and Obstetrics, Xiangyang No.1 People's Hospital, Hubei University of Medcine, Xiangyang, 441000, China. gelanxiu123@163.com.
Abstract
BACKGROUND: Iodine plays an important role in pregnancy. How to maintain adequate iodine intake amongst pregnant women in each trimester of pregnancy to prevent adverse birth outcomes in central China is a challenge for clinical practice. METHODS: 870 pregnant women and their infants were enrolled in the study. Urinary iodine concentration (UIC) was measured using an inductively coupled plasma mass spectrometry (ICP-MS). Maternal and newborn information were obtained during follow-up. Multinomial logistic regression models were established. RESULTS: Median UIC of pregnant women was 172 ± 135 μg/L which is currently considered to be sufficient. Multivitamin supplements containing iodine, iodized salt intake and frequent milk intake were significantly associated with higher UIC. Multivariate logistic regression analysis showed that multivitamin supplements containing iodine and milk consumption were risk factors for more than adequate iodine (UIC ≥ 250 μg/L). Iodine-rich diet was significantly related to heavier birthweight, larger head circumference and longer femur length of the newborns while more than adequate iodine intake (UIC ≥ 250 μg/L) was a risk factor for macrosomia. Logistic regression models based on potential risk factors involving iodine containing supplements and iodine-rich diet were established to predict and screen pregnant women with high risk of more than adequate iodine intake among local pregnant women in different trimesters and guide them to supplement iodine reasonably to prevent the risk. CONCLUSIONS: Multivitamin supplements containing iodine and milk consumption were risk factors for maternal UIC ≥ 250 μg/L which was a risk factor for macrosomia. Iodine monitoring models were established to provide guidance for pregnant women to reduce the risk of more than adequate iodine intake, thereby contributing to reduce the risk of having a macrosomia.
BACKGROUND:Iodine plays an important role in pregnancy. How to maintain adequate iodine intake amongst pregnant women in each trimester of pregnancy to prevent adverse birth outcomes in central China is a challenge for clinical practice. METHODS: 870 pregnant women and their infants were enrolled in the study. Urinary iodine concentration (UIC) was measured using an inductively coupled plasma mass spectrometry (ICP-MS). Maternal and newborn information were obtained during follow-up. Multinomial logistic regression models were established. RESULTS: Median UIC of pregnant women was 172 ± 135 μg/L which is currently considered to be sufficient. Multivitamin supplements containing iodine, iodized salt intake and frequent milk intake were significantly associated with higher UIC. Multivariate logistic regression analysis showed that multivitamin supplements containing iodine and milk consumption were risk factors for more than adequate iodine (UIC ≥ 250 μg/L). Iodine-rich diet was significantly related to heavier birthweight, larger head circumference and longer femur length of the newborns while more than adequate iodine intake (UIC ≥ 250 μg/L) was a risk factor for macrosomia. Logistic regression models based on potential risk factors involving iodine containing supplements and iodine-rich diet were established to predict and screen pregnant women with high risk of more than adequate iodine intake among local pregnant women in different trimesters and guide them to supplement iodine reasonably to prevent the risk. CONCLUSIONS: Multivitamin supplements containing iodine and milk consumption were risk factors for maternal UIC ≥ 250 μg/L which was a risk factor for macrosomia. Iodine monitoring models were established to provide guidance for pregnant women to reduce the risk of more than adequate iodine intake, thereby contributing to reduce the risk of having a macrosomia.
Entities:
Keywords:
Macrosomia; Monitoring model; More than adequate iodine
Authors: W C Allan; J E Haddow; G E Palomaki; J R Williams; M L Mitchell; R J Hermos; J D Faix; R Z Klein Journal: J Med Screen Date: 2000 Impact factor: 2.136
Authors: Mark P J Vanderpump; John H Lazarus; Peter P Smyth; Peter Laurberg; Roger L Holder; Kristien Boelaert; Jayne A Franklyn Journal: Lancet Date: 2011-06-02 Impact factor: 79.321
Authors: Ming Qian; Dong Wang; William E Watkins; Val Gebski; Yu Qin Yan; Mu Li; Zu Pei Chen Journal: Asia Pac J Clin Nutr Date: 2005 Impact factor: 1.662
Authors: Gabriella Morreale de Escobar; María Jesús Obregón; Francisco Escobar del Rey Journal: Best Pract Res Clin Endocrinol Metab Date: 2004-06 Impact factor: 4.690
Authors: Sarah C Bath; Victoria L Furmidge-Owen; Christopher Wg Redman; Margaret P Rayman Journal: Am J Clin Nutr Date: 2015-05-06 Impact factor: 7.045