| Literature DB >> 34182361 |
Dariane Trivisiol da Silva1, Franciele Aline Smaniotto2, Isabella Ferreira Costa2, Julia Baranzelli2, Aline Muller2, Sabrina Somacal2, Camila Sant'Anna Monteiro2, Márcia Vizzotto3, Eliseu Rodrigues4, Milene Teixeira Barcia2, Tatiana Emanuelli5.
Abstract
This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins.Entities:
Keywords: Absorption; Anthocyanins; Green solvent; Intestinal stability; Metabolites; Pharmacokinetic
Year: 2021 PMID： 34182361 DOI： 10.1016/j.foodchem.2021.130370
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514