Literature DB >> 34181839

Perioperative protocol to reduce blood transfusions in total knee o hip replacement patients

Alejandro Godoy1, Jaqueline Gonzalez2, Ana Florencia Becerra3, Mariano Finola4, Facundo Faule5, Carlos Estrada6, Yamile Neder7, Ricardo Albertini8.   

Abstract

Introduction: Patient Blood Management (PBM) programs improve patient care and reduce health costs. It includes detection of presurgical anemia, reduction of blood loss and improvement of patient-specific anemic reserve. The aim of this study is to assess the effect of a PBM program on transfusion rate, length of stay (LOS) and adverse events.
Methods: We developed a retrospective observational study. We included patients who underwent total hip (THR) o knee replacement (TKR). Our PBM involved preoperative assessment, administration of 2 doses of tranexamic acid, application of restrictive transfusion criteria and use of IV iron. We compared results between the group of patients before and the one after the PBM implementation.
Results: We included 179 patients (80 TKR and 99 THR) who underwent surgery before PBM implementation from January to December 2014 (Group A), and 187 patients (103 TKR and 84 THR) who underwent arthroplasty after PBM application from January to November 2016 (Group B). In Group A, hemoglobin drop was larger than in Group B, for TKR (5.1±1.2 vs. 4.2±1.2 g/dl; p<0,05) and for THR (4.7±1.3 vs. 3.8±1.3 g/dl; p<0,05). In group A, more patients were transfused (31.8% vs. 2.7%; p<0.001). LOS was longer for patients in group A, in both surgeries (for TKA, 3.98±1.4days vs. 2.99±0.95 days; p<0.0001; for THA 3.68±1.06days vs. 2.88±0.75days; p<0.0001). No significant differences were found regarding adverse events.
Conclusion: Our PBM program saved transfusions after primary TKR and THR and lowered LOS, without risking patients to higher number of complications or death. Universidad Nacional de Córdoba

Entities:  

Keywords:  arthroplasty replacement; blood transfusion; anemia; Tranexamic Acid

Mesh:

Year:  2021        PMID: 34181839      PMCID: PMC8741308          DOI: 10.31053/1853.0605.v78.n2.30134

Source DB:  PubMed          Journal:  Rev Fac Cien Med Univ Nac Cordoba        ISSN: 0014-6722


  25 in total

1.  Blood transfusion: summary of NICE guidance.

Authors:  Smita Padhi; Sophia Kemmis-Betty; Sharangini Rajesh; Jennifer Hill; Michael F Murphy
Journal:  BMJ       Date:  2015-11-18

Review 2.  Comparison of intravenous versus topical tranexamic acid in primary total hip and knee arthroplasty: An updated meta-analysis.

Authors:  Jinwei Xie; Qinsheng Hu; Qiang Huang; Jun Ma; Yiting Lei; Fuxing Pei
Journal:  Thromb Res       Date:  2017-03-10       Impact factor: 3.944

3.  Implementing Patient Blood Management in major orthopaedic procedures: orthodoxy or pragmatism?

Authors:  Manuel Muñoz; Susana Gómez-Ramírez; José A García-Erce
Journal:  Blood Transfus       Date:  2014-04       Impact factor: 3.443

4.  Combined use of intravenous and topical tranexamic acid following cementless total hip arthroplasty: a randomised clinical trial.

Authors:  Jinwei Xie; Jun Ma; Chen Yue; Pengde Kang; Fuxing Pei
Journal:  Hip Int       Date:  2015-09-09       Impact factor: 2.135

5.  Intravenous vs Intra-Articular Tranexamic Acid in Total Knee Arthroplasty: A Randomized, Double-Blind Trial.

Authors:  Navendu Goyal; Darren B Chen; Ian A Harris; Neville J Rowden; George Kirsh; Samuel J MacDessi
Journal:  J Arthroplasty       Date:  2016-07-15       Impact factor: 4.757

Review 6.  Concepts of blood transfusion in adults.

Authors:  Lawrence T Goodnough; Jerrold H Levy; Michael F Murphy
Journal:  Lancet       Date:  2013-05-25       Impact factor: 79.321

7.  The Efficacy of Tranexamic Acid in Total Hip Arthroplasty: A Network Meta-analysis.

Authors:  Yale A Fillingham; Dipak B Ramkumar; David S Jevsevar; Adolph J Yates; Peter Shores; Kyle Mullen; Stefano A Bini; Henry D Clarke; Emil Schemitsch; Rebecca L Johnson; Stavros G Memtsoudis; Siraj A Sayeed; Alexander P Sah; Craig J Della Valle
Journal:  J Arthroplasty       Date:  2018-06-27       Impact factor: 4.757

8.  The Assessment of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous vs Intracapsular Administration of Tranexamic Acid.

Authors:  Jedediah H May; Geoffrey R Rieser; Chad G Williams; Ronald J Markert; Ryan D Bauman; Matthew W Lawless
Journal:  J Arthroplasty       Date:  2016-04-30       Impact factor: 4.757

9.  Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety.

Authors:  Jashvant Poeran; Rehana Rasul; Suzuko Suzuki; Thomas Danninger; Madhu Mazumdar; Mathias Opperer; Friedrich Boettner; Stavros G Memtsoudis
Journal:  BMJ       Date:  2014-08-12

Review 10.  A systematic review and meta-analysis comparing combined intravenous and topical tranexamic acid with intravenous administration alone in THA.

Authors:  Yangbai Sun; Chaoyin Jiang; Qingfeng Li
Journal:  PLoS One       Date:  2017-10-10       Impact factor: 3.240

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