Volker A Coenen1,2,3, Bastian E Sajonz4,5, Peter C Reinacher4,5,6, Christoph P Kaller5,7, Horst Urbach5,7, M Reisert4,5,8. 1. Department of Stereotactic and Functional Neurosurgery, Medical Center of Freiburg University, Breisacher Strasse 64, 79106, Freiburg i.Br, Germany. volker.coenen@uniklinik-freiburg.de. 2. Medical Faculty of Freiburg University, Freiburg, Germany. volker.coenen@uniklinik-freiburg.de. 3. Center for Deep Brain Stimulation, Medical Center of Freiburg University, Freiburg, Germany. volker.coenen@uniklinik-freiburg.de. 4. Department of Stereotactic and Functional Neurosurgery, Medical Center of Freiburg University, Breisacher Strasse 64, 79106, Freiburg i.Br, Germany. 5. Medical Faculty of Freiburg University, Freiburg, Germany. 6. Fraunhofer Institute for Laser Technology, Aachen, Germany. 7. Department of Neuroradiology, Freiburg University Medical Center, Freiburg, Germany. 8. Department of Radiology - Medical Physics, Freiburg University, Freiburg, Germany.
Abstract
BACKGROUND: An increasing number of neurosurgeons use display of the dentato-rubro-thalamic tract (DRT) based on diffusion weighted imaging (dMRI) as basis for their routine planning of stimulation or lesioning approaches in stereotactic tremor surgery. An evaluation of the anatomical validity of the display of the DRT with respect to modern stereotactic planning systems and across different tracking environments has not been performed. METHODS: Distinct dMRI and anatomical magnetic resonance imaging (MRI) data of high and low quality from 9 subjects were used. Six subjects had repeated MRI scans and therefore entered the analysis twice. Standardized DICOM structure templates for volume of interest definition were applied in native space for all investigations. For tracking BrainLab Elements (BrainLab, Munich, Germany), two tensor deterministic tracking (FT2), MRtrix IFOD2 ( https://www.mrtrix.org ), and a global tracking (GT) approach were used to compare the display of the uncrossed (DRTu) and crossed (DRTx) fiber structure after transformation into MNI space. The resulting streamlines were investigated for congruence, reproducibility, anatomical validity, and penetration of anatomical way point structures. RESULTS: In general, the DRTu can be depicted with good quality (as judged by waypoints). FT2 (surgical) and GT (neuroscientific) show high congruence. While GT shows partly reproducible results for DRTx, the crossed pathway cannot be reliably reconstructed with the other (iFOD2 and FT2) algorithms. CONCLUSION: Since a direct anatomical comparison is difficult in the individual subjects, we chose a comparison with two research tracking environments as the best possible "ground truth." FT2 is useful especially because of its manual editing possibilities of cutting erroneous fibers on the single subject level. An uncertainty of 2 mm as mean displacement of DRTu is expectable and should be respected when using this approach for surgical planning. Tractographic renditions of the DRTx on the single subject level seem to be still illusive.
BACKGROUND: An increasing number of neurosurgeons use display of the dentato-rubro-thalamic tract (DRT) based on diffusion weighted imaging (dMRI) as basis for their routine planning of stimulation or lesioning approaches in stereotactic tremor surgery. An evaluation of the anatomical validity of the display of the DRT with respect to modern stereotactic planning systems and across different tracking environments has not been performed. METHODS: Distinct dMRI and anatomical magnetic resonance imaging (MRI) data of high and low quality from 9 subjects were used. Six subjects had repeated MRI scans and therefore entered the analysis twice. Standardized DICOM structure templates for volume of interest definition were applied in native space for all investigations. For tracking BrainLab Elements (BrainLab, Munich, Germany), two tensor deterministic tracking (FT2), MRtrix IFOD2 ( https://www.mrtrix.org ), and a global tracking (GT) approach were used to compare the display of the uncrossed (DRTu) and crossed (DRTx) fiber structure after transformation into MNI space. The resulting streamlines were investigated for congruence, reproducibility, anatomical validity, and penetration of anatomical way point structures. RESULTS: In general, the DRTu can be depicted with good quality (as judged by waypoints). FT2 (surgical) and GT (neuroscientific) show high congruence. While GT shows partly reproducible results for DRTx, the crossed pathway cannot be reliably reconstructed with the other (iFOD2 and FT2) algorithms. CONCLUSION: Since a direct anatomical comparison is difficult in the individual subjects, we chose a comparison with two research tracking environments as the best possible "ground truth." FT2 is useful especially because of its manual editing possibilities of cutting erroneous fibers on the single subject level. An uncertainty of 2 mm as mean displacement of DRTu is expectable and should be respected when using this approach for surgical planning. Tractographic renditions of the DRTx on the single subject level seem to be still illusive.
Authors: Lena V Schumacher; Marco Reisert; Kai Nitschke; Karl Egger; Horst Urbach; Jürgen Hennig; Cornelius Weiller; Christoph P Kaller Journal: Neuroimage Date: 2018-02-10 Impact factor: 6.556
Authors: A L Benabid; P Pollak; C Gervason; D Hoffmann; D M Gao; M Hommel; J E Perret; J de Rougemont Journal: Lancet Date: 1991-02-16 Impact factor: 79.321
Authors: J Mollink; K M van Baarsen; P J W C Dederen; S Foxley; K L Miller; S Jbabdi; C H Slump; J A Grotenhuis; M Kleinnijenhuis; A M van Cappellen van Walsum Journal: Brain Struct Funct Date: 2015-10-05 Impact factor: 3.270
Authors: P Riva-Posse; K S Choi; P E Holtzheimer; A L Crowell; S J Garlow; J K Rajendra; C C McIntyre; R E Gross; H S Mayberg Journal: Mol Psychiatry Date: 2017-04-11 Impact factor: 15.992
Authors: Albert J Fenoy; Paul E Schulz; Sudhakar Selvaraj; Christina L Burrows; Giovanna Zunta-Soares; Kathryn Durkin; Paolo Zanotti-Fregonara; Joao Quevedo; Jair C Soares Journal: Transl Psychiatry Date: 2018-06-04 Impact factor: 6.222
Authors: Till A Dembek; Jan Niklas Petry-Schmelzer; Paul Reker; Jochen Wirths; Stefanie Hamacher; Julia Steffen; Haidar S Dafsari; Mauritius Hövels; Gereon R Fink; Veerle Visser-Vandewalle; Michael T Barbe Journal: Neuroimage Clin Date: 2020-03-04 Impact factor: 4.881