Literature DB >> 34179248

Common Carotid Arteries Occlusion Surgery in Adult Rats as a Model of Chronic Cerebral Hypoperfusion.

Dandan Cao1, Yunfei Bai1, Liang Li1.   

Abstract

Chronic cerebral hypoperfusion (CCH) is an important risk factor of vascular dementia (VaD) and Alzheimer's disease (AD). Hypoxia/ischemia in the whole brain induced by CCH causes serious damage to brain structure and function, which can lead to cognitive impairment. Two-vessel occlusion (2-VO), also known as permanent, bilateral common carotid artery occlusion, is one of the most widely used animal models (e.g., rat) of CCH to investigate the mechanisms of neurodegenerative processes. In this protocol, we present the surgical procedure for 2-VO in rats.
Copyright © 2018 The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Alzheimer’s disease; Cerebral blood flow; Chronic cerebral hypoperfusion; Two-vessel occlusion; Vascular dementia; White matter

Year:  2018        PMID： 34179248      PMCID： PMC8203935          DOI： 10.21769/BioProtoc.2704

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  22 in total

Review 1.  Vascular basis of Alzheimer's pathogenesis.

Authors:  J C de la Torre
Journal:  Ann N Y Acad Sci       Date:  2002-11       Impact factor: 5.691

Review 2.  Cerebral blood flow and metabolic abnormalities in Alzheimer's disease.

Authors:  H Matsuda
Journal:  Ann Nucl Med       Date:  2001-04       Impact factor: 2.668

Review 3.  Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models.

Authors:  Cristina Sarti; Leonardo Pantoni; Luciano Bartolini; Domenico Inzitari
Journal:  J Neurol Sci       Date:  2002-11-15       Impact factor: 3.181

4.  Long-term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model.

Authors:  Tatsuo Otori; Toshiya Katsumata; Hiromi Muramatsu; Fumihiko Kashiwagi; Yasuo Katayama; Akiro Terashi
Journal:  Clin Exp Pharmacol Physiol       Date:  2003-04       Impact factor: 2.557

5.  Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat.

Authors:  Hideaki Wakita; Hidekazu Tomimoto; Ichiro Akiguchi; Akinori Matsuo; Jin Xi Lin; Masafumi Ihara; Patrick L McGeer
Journal:  Brain Res       Date:  2002-01-04       Impact factor: 3.252

6.  Transient changes of brain-derived neurotrophic factor (BDNF) mRNA expression in hippocampus during moderate ischemia induced by chronic bilateral common carotid artery occlusions in the rat.

Authors:  R Schmidt-Kastner; J Truettner; B Lin; W Zhao; I Saul; R Busto; M D Ginsberg
Journal:  Brain Res Mol Brain Res       Date:  2001-08-15

7.  Inhibitory avoidance memory retention in the elevated T-maze is impaired after perivascular manipulation of the common carotid arteries.

Authors:  Valquíria Camin de Bortoli; Hélio Zangrossi Júnior; Fernando Morgan de Aguiar Corrêa; Sebastião de Sousa Almeida; Ana Maria de Oliveira
Journal:  Life Sci       Date:  2005-03-18       Impact factor: 5.037

8.  Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion.

Authors:  Eszter Farkas; Adám Institóris; Ferenc Domoki; András Mihály; Paul G M Luiten; Ferenc Bari
Journal:  Brain Res       Date:  2004-05-22       Impact factor: 3.252

9.  Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat.

Authors:  H Tomimoto; M Ihara; H Wakita; R Ohtani; J-X Lin; I Akiguchi; M Kinoshita; H Shibasaki
Journal:  Acta Neuropathol       Date:  2003-09-11       Impact factor: 17.088

Review 10.  Astrocytes in cerebral ischemic injury: morphological and general considerations.

Authors:  Kiran S Panickar; Michael D Norenberg
Journal:  Glia       Date:  2005-06       Impact factor: 8.073
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  1 in total

Review 1.  Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus on Preclinical Investigations.

Authors:  Trisha A Jenkins
Journal:  Curr Diab Rep       Date:  2022-06-23       Impact factor: 5.430
  1 in total

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