Literature DB >> 34179226

A Rodent Model for Chronic Brain Hypoperfusion Related Diseases: Permanent Bilateral Occlusion of the Common Carotid Arteries (2VO) in Rats.

Mei-Ling Yan1, Jing Ai1.   

Abstract

Permanent occlusion of bilateral common carotid arteries (2VO) in rat is considered as a suitable animal model to mimic chronic brain hypoperfusion status, which is proved to be a risk factor to precede the Alzheimer's disease or/and vascular dementia. In this protocol, we describe how to successfully ligate the bilateral common carotid arteries covered by anterior cervical muscle group, and provide the details for understanding the surgical procedures of 2VO.
Copyright © 2018 The Authors; exclusive licensee Bio-protocol LLC.

Entities:  

Keywords:  Chronic brain hypoperfusion; Permanent occlusion of bilateral common carotid arteries; Rat

Year:  2018        PMID： 34179226      PMCID： PMC8203864          DOI： 10.21769/BioProtoc.2668

Source DB:  PubMed          Journal:  Bio Protoc        ISSN： 2331-8325


  16 in total

Review 1.  Aspects of ageing in chronic cerebral oligaemia. Mechanisms of degeneration and compensation in rat models.

Authors:  K Plaschke
Journal:  J Neural Transm (Vienna)       Date:  2004-07-28       Impact factor: 3.575

2.  Long-term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model.

Authors:  Tatsuo Otori; Toshiya Katsumata; Hiromi Muramatsu; Fumihiko Kashiwagi; Yasuo Katayama; Akiro Terashi
Journal:  Clin Exp Pharmacol Physiol       Date:  2003-04       Impact factor: 2.557

3.  Relationship between cholinergic dysfunction and discrimination learning disabilities in Wistar rats following chronic cerebral hypoperfusion.

Authors:  K Tanaka; N Ogawa; M Asanuma; Y Kondo; M Nomura
Journal:  Brain Res       Date:  1996-08-05       Impact factor: 3.252

4.  The effect of bilateral carotid artery ligation upon the blood flow and the energy state of the rat brain.

Authors:  B Eklöf; B K Siesjö
Journal:  Acta Physiol Scand       Date:  1972-10

5.  Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats.

Authors:  H Ohta; H Nishikawa; H Kimura; H Anayama; M Miyamoto
Journal:  Neuroscience       Date:  1997-08       Impact factor: 3.590

6.  Early microglial reaction following mild forebrain ischemia induced by common carotid artery occlusion in rats.

Authors:  H Abrahám; G Lázár
Journal:  Brain Res       Date:  2000-04-17       Impact factor: 3.252

Review 7.  Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association.

Authors:  Philip B Gorelick; Angelo Scuteri; Sandra E Black; Charles Decarli; Steven M Greenberg; Costantino Iadecola; Lenore J Launer; Stephane Laurent; Oscar L Lopez; David Nyenhuis; Ronald C Petersen; Julie A Schneider; Christophe Tzourio; Donna K Arnett; David A Bennett; Helena C Chui; Randall T Higashida; Ruth Lindquist; Peter M Nilsson; Gustavo C Roman; Frank W Sellke; Sudha Seshadri
Journal:  Stroke       Date:  2011-07-21       Impact factor: 7.914

Review 8.  Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases.

Authors:  Eszter Farkas; Paul G M Luiten; Ferenc Bari
Journal:  Brain Res Rev       Date:  2007-01-18

9.  Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats.

Authors:  D Kumaran; M Udayabanu; M Kumar; R Aneja; A Katyal
Journal:  Neuroscience       Date:  2008-06-17       Impact factor: 3.590

10.  Chronic cerebral hypoperfusion induces white matter lesions and loss of oligodendroglia with DNA fragmentation in the rat.

Authors:  H Tomimoto; M Ihara; H Wakita; R Ohtani; J-X Lin; I Akiguchi; M Kinoshita; H Shibasaki
Journal:  Acta Neuropathol       Date:  2003-09-11       Impact factor: 17.088
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