Literature DB >> 34178170

From chronology to the biology of aging, and its tuning by mitochondrial health: overview of the Bioenergetics, Mitochondria, and Metabolism subgroup symposium at the 2021 Virtual 65th Annual Meeting of the Biophysical Society.

Sonia Cortassa1, Miguel A Aon1,2.   

Abstract

A distinguished group of researchers congregated at one of the symposia during the 2021 Virtual Meeting organized by the Biophysical Society, to speak about the critically important role played by mitochondrial functionality in healthy aging. The latest research trends expressed by the speakers during the meeting resulted in an updated display of novel emerging molecular targets involved in keeping mitochondrial health during metabolic disorder and until late in life. Besides offering insightful views on the impact of mitochondrial healthy function on the biology of aging in different organs such as the liver and cardiac and skeletal muscle, their distinct experimental approaches showed a significant convergence in results, a reassuring hallmark of scientific excellence. The interdisciplinary crossroad of biology, biophysics, and biochemistry, evidenced during the symposium organized by the Bioenergetics, Mitochondria, and Metabolism subgroup, is another example of fruitful collaboration at one of the scientific frontiers represented by human aging. © This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2021.

Entities:  

Keywords:  Mitochondrial function; healthspan; lifespan; nutrient sensing

Year:  2021        PMID: 34178170      PMCID: PMC8214635          DOI: 10.1007/s12551-021-00808-7

Source DB:  PubMed          Journal:  Biophys Rev        ISSN: 1867-2450


  12 in total

1.  The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.

Authors:  Michael N Davies; Lilja Kjalarsdottir; J Will Thompson; Laura G Dubois; Robert D Stevens; Olga R Ilkayeva; M Julia Brosnan; Timothy P Rolph; Paul A Grimsrud; Deborah M Muoio
Journal:  Cell Rep       Date:  2015-12-31       Impact factor: 9.423

Review 2.  The Aging Heart.

Authors:  Ying Ann Chiao; Peter S Rabinovitch
Journal:  Cold Spring Harb Perspect Med       Date:  2015-09-01       Impact factor: 6.915

3.  Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.

Authors:  Shinichi Someya; Wei Yu; William C Hallows; Jinze Xu; James M Vann; Christiaan Leeuwenburgh; Masaru Tanokura; John M Denu; Tomas A Prolla
Journal:  Cell       Date:  2010-11-24       Impact factor: 41.582

4.  The CoQH2/CoQ Ratio Serves as a Sensor of Respiratory Chain Efficiency.

Authors:  Adela Guarás; Ester Perales-Clemente; Enrique Calvo; Rebeca Acín-Pérez; Marta Loureiro-Lopez; Claire Pujol; Isabel Martínez-Carrascoso; Estefanía Nuñez; Fernando García-Marqués; María Angeles Rodríguez-Hernández; Ana Cortés; Francisca Diaz; Acisclo Pérez-Martos; Carlos T Moraes; Patricio Fernández-Silva; Aleksandra Trifunovic; Plácido Navas; Jesús Vazquez; Jose A Enríquez
Journal:  Cell Rep       Date:  2016-03-24       Impact factor: 9.423

Review 5.  The hallmarks of aging.

Authors:  Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

6.  ADCK2 Haploinsufficiency Reduces Mitochondrial Lipid Oxidation and Causes Myopathy Associated with CoQ Deficiency.

Authors:  Luis Vázquez-Fonseca; Jochen Schaefer; Ignacio Navas-Enamorado; Carlos Santos-Ocaña; Juan D Hernández-Camacho; Ignacio Guerra; María V Cascajo; Ana Sánchez-Cuesta; Zoltan Horvath; Emilio Siendones; Cristina Jou; Mercedes Casado; Purificación Gutiérrez; Gloria Brea-Calvo; Guillermo López-Lluch; Daniel J M Fernández-Ayala; Ana B Cortés-Rodríguez; Juan C Rodríguez-Aguilera; Cristiane Matté; Antonia Ribes; Sandra Y Prieto-Soler; Eduardo Dominguez-Del-Toro; Andrea di Francesco; Miguel A Aon; Michel Bernier; Leonardo Salviati; Rafael Artuch; Rafael de Cabo; Sandra Jackson; Plácido Navas
Journal:  J Clin Med       Date:  2019-09-02       Impact factor: 4.241

Review 7.  Measuring biological aging in humans: A quest.

Authors:  Luigi Ferrucci; Marta Gonzalez-Freire; Elisa Fabbri; Eleanor Simonsick; Toshiko Tanaka; Zenobia Moore; Shabnam Salimi; Felipe Sierra; Rafael de Cabo
Journal:  Aging Cell       Date:  2019-12-12       Impact factor: 9.304

8.  NQO1 protects obese mice through improvements in glucose and lipid metabolism.

Authors:  Andrea Di Francesco; Youngshim Choi; Michel Bernier; Yingchun Zhang; Alberto Diaz-Ruiz; Miguel A Aon; Krystle Kalafut; Margaux R Ehrlich; Kelsey Murt; Ahmed Ali; Kevin J Pearson; Sophie Levan; Joshua D Preston; Alejandro Martin-Montalvo; Jennifer L Martindale; Kotb Abdelmohsen; Cole R Michel; Diana M Willmes; Christine Henke; Placido Navas; Jose Manuel Villalba; David Siegel; Myriam Gorospe; Kristofer Fritz; Shyam Biswal; David Ross; Rafael de Cabo
Journal:  NPJ Aging Mech Dis       Date:  2020-11-19

9.  A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice.

Authors:  Michael A Petr; Irene Alfaras; Melissa Krawcyzk; Woei-Nan Bair; Sarah J Mitchell; Christopher H Morrell; Stephanie A Studenski; Nathan L Price; Kenneth W Fishbein; Richard G Spencer; Morten Scheibye-Knudsen; Edward G Lakatta; Luigi Ferrucci; Miguel A Aon; Michel Bernier; Rafael de Cabo
Journal:  Elife       Date:  2021-04-20       Impact factor: 8.140

10.  Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice.

Authors:  Ying Ann Chiao; Huiliang Zhang; Mariya Sweetwyne; Jeremy Whitson; Ying Sonia Ting; Nathan Basisty; Lindsay K Pino; Ellen Quarles; Ngoc-Han Nguyen; Matthew D Campbell; Tong Zhang; Matthew J Gaffrey; Gennifer Merrihew; Lu Wang; Yongping Yue; Dongsheng Duan; Henk L Granzier; Hazel H Szeto; Wei-Jun Qian; David Marcinek; Michael J MacCoss; Peter Rabinovitch
Journal:  Elife       Date:  2020-07-10       Impact factor: 8.140

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