Literature DB >> 34176283

Targeting MicroRNA-192-5p, a Downstream Effector of NOXs (NADPH Oxidases), Reverses Endothelial DHFR (Dihydrofolate Reductase) Deficiency to Attenuate Abdominal Aortic Aneurysm Formation.

Kai Huang1,2, Taro Narumi1,2, Yixuan Zhang1,2, Qiang Li1,2, Priya Murugesan1,2, Yusi Wu1,2, Norika Mengchia Liu1,2, Hua Cai1,2.   

Abstract

[Figure: see text].

Entities:  

Keywords:  NADPH oxidase; angiotensin II; aortic aneurysm, abdominal; dihydrofolate reductase; endothelial nitric oxide synthase; microRNA; oxidative stress

Mesh：

Substances：

Year:  2021        PMID： 34176283      PMCID： PMC8266749          DOI： 10.1161/HYPERTENSIONAHA.120.15070

Source DB:  PubMed          Journal:  Hypertension        ISSN： 0194-911X            Impact factor:   9.897


  41 in total

1.  Analysis of Cell Type-Specific Effects of MicroRNA-92a Provides Novel Insights Into Target Regulation and Mechanism of Action.

Authors:  Eva-Maria Rogg; Wesley T Abplanalp; Corinne Bischof; David John; Marcel H Schulz; Jaya Krishnan; Ariane Fischer; Chiara Poluzzi; Liliana Schaefer; Angelika Bonauer; Andreas M Zeiher; Stefanie Dimmeler
Journal:  Circulation       Date:  2018-11-27       Impact factor: 29.690

2.  Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial.

Authors:  Rajesh Patel; Michael J Sweeting; Janet T Powell; Roger M Greenhalgh
Journal:  Lancet       Date:  2016-10-12       Impact factor: 79.321

Review 3.  NAD(P)H oxidase-dependent self-propagation of hydrogen peroxide and vascular disease.

Authors:  Hua Cai
Journal:  Circ Res       Date:  2005-04-29       Impact factor: 17.367

4.  Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.

Authors:  Manesh Thomas; Dan Gavrila; Michael L McCormick; Francis J Miller; Alan Daugherty; Lisa A Cassis; Kevin C Dellsperger; Neal L Weintraub
Journal:  Circulation       Date:  2006-07-24       Impact factor: 29.690

5.  Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications.

Authors:  Xiao Niu Miao; Kin Lung Siu; Hua Cai
Journal:  J Mol Cell Cardiol       Date:  2015-08-04       Impact factor: 5.000

6.  miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit.

Authors:  Bo Song; Yuan Wang; Kenji Kudo; Elaine J Gavin; Yaguang Xi; Jingfang Ju
Journal:  Clin Cancer Res       Date:  2008-12-15       Impact factor: 12.531

7.  An ezrin/calpain/PI3K/AMPK/eNOSs1179 signaling cascade mediating VEGF-dependent endothelial nitric oxide production.

Authors:  Ji-Youn Youn; Ting Wang; Hua Cai
Journal:  Circ Res       Date:  2008-11-26       Impact factor: 17.367

8.  Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways.

Authors:  Tetsushi Nakao; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tomohiro Nishino; Masayasu Izuhara; Yasuhide Kuwabara; Hitoo Nishi; Shunsuke Usami; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Naoya Sowa; Satoko Ohno; Hiroki Aoki; Koji Hasegawa; Kazuhisa Sakamoto; Kenji Minatoya; Takeshi Kimura; Koh Ono
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-09-07       Impact factor: 8.311

9.  MicroRNA-33 protects against neointimal hyperplasia induced by arterial mechanical stretch in the grafted vein.

Authors:  Kai Huang; Han Bao; Zhi-Qiang Yan; Lu Wang; Ping Zhang; Qing-Ping Yao; Qian Shi; Xiao-Hu Chen; Kai-Xuan Wang; Bao-Rong Shen; Ying-Xin Qi; Zong-Lai Jiang
Journal:  Cardiovasc Res       Date:  2017-04-01       Impact factor: 10.787

10.  NOX isoforms in the development of abdominal aortic aneurysm.

Authors:  Kin Lung Siu; Qiang Li; Yixuan Zhang; Jun Guo; Ji Youn Youn; Jie Du; Hua Cai
Journal:  Redox Biol       Date:  2016-11-19       Impact factor: 11.799
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  1 in total

1.  Robust therapeutic effects on COVID-19 of novel small molecules: Alleviation of SARS-CoV-2 S protein induction of ACE2/TMPRSS2, NOX2/ROS, and MCP-1.

Authors:  Ji Youn Youn; Jian Wang; Qian Li; Kai Huang; Hua Cai
Journal:  Front Cardiovasc Med       Date:  2022-09-15
  1 in total

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