Literature DB >> 3417559

BMY-28438 (3,7-dihydroxytropolone), a new antitumor antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity.

K Sugawara1, M Ohbayashi, K Shimizu, M Hatori, H Kamei, M Konishi, T Oki, H Kawaguchi.   

Abstract

A new antitumor antibiotic BMY-28438 was isolated from the cultured broth of Streptomyces tropolofaciens No. K611-97. The antibiotic showed potent cytotoxicity against cultured B16 melanoma cells and remarkable prolongation of life span of mice bearing B16 melanoma. The structure of BMY-28438 was determined as 3,7-dihydroxytropolone on the basis of spectral analyses and direct comparison with the authentic compound synthesized.

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Year:  1988        PMID： 3417559     DOI： 10.7164/antibiotics.41.862

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  9 in total

1.  Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring.

Authors:  Xuefei Chen; Min Xu; Jin Lü; Jianguo Xu; Yemin Wang; Shuangjun Lin; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2018-05-31       Impact factor: 4.792

2.  Synthetic α-Hydroxytropolones Inhibit Replication of Wild-Type and Acyclovir-Resistant Herpes Simplex Viruses.

Authors:  Peter J Ireland; John E Tavis; Michael P D'Erasmo; Danielle R Hirsch; Ryan P Murelli; Mark M Cadiz; Bindi S Patel; Ankit K Gupta; Tiffany C Edwards; Maria Korom; Eileen A Moran; Lynda A Morrison
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

3.  Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.

Authors:  Gaofeng Lu; Elena Lomonosova; Xiaohong Cheng; Eileen A Moran; Marvin J Meyers; Stuart F J Le Grice; Craig J Thomas; Jian-kang Jiang; Christine Meck; Danielle R Hirsch; Michael P D'Erasmo; Duygu M Suyabatmaz; Ryan P Murelli; John E Tavis
Journal:  Antimicrob Agents Chemother       Date:  2014-12-01       Impact factor: 5.191

4.  Synthesis of Polyoxygenated Tropolones and their Antiviral Activity against Hepatitis B Virus and Herpes Simplex Virus-1.

Authors:  Daniel V Schiavone; Diana M Kapkayeva; Qilan Li; Molly E Woodson; Andreu Gazquez Casals; Lynda A Morrison; John E Tavis; Ryan P Murelli
Journal:  Chemistry       Date:  2022-01-31       Impact factor: 5.236

5.  Identification of 4-isopropyl-thiotropolone as a novel anti-microbial: regioselective synthesis, NMR characterization, and biological evaluation.

Authors:  Mohamed Elagawany; Lamees Hegazy; Feng Cao; Maureen J Donlin; Nigam Rath; John Tavis; Bahaa Elgendy
Journal:  RSC Adv       Date:  2018-08-23       Impact factor: 4.036

6.  Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis.

Authors:  Jin Li; Eric R Falcone; Sarah A Holstein; Amy C Anderson; Dennis L Wright; Andrew J Wiemer
Journal:  Pharmacol Res       Date:  2016-09-20       Impact factor: 7.658

7.  The biology and synthesis of α-hydroxytropolones.

Authors:  Christine Meck; Michael P D'Erasmo; Danielle R Hirsch; Ryan P Murelli
Journal:  Medchemcomm       Date:  2014-07-01       Impact factor: 3.597

8.  Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.

Authors:  Scott R Budihas; Inna Gorshkova; Sergei Gaidamakov; Antony Wamiru; Marion K Bona; Michael A Parniak; Robert J Crouch; James B McMahon; John A Beutler; Stuart F J Le Grice
Journal:  Nucleic Acids Res       Date:  2005-03-01       Impact factor: 16.971

Review 9.  Bacterial Tropone Natural Products and Derivatives: Overview of their Biosynthesis, Bioactivities, Ecological Role and Biotechnological Potential.

Authors:  Ying Duan; Melanie Petzold; Raspudin Saleem-Batcha; Robin Teufel
Journal:  Chembiochem       Date:  2020-05-08       Impact factor: 3.164
  9 in total

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