Jonathan J Lyons1. 1. Translational Allergic Immunopathology Unit, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address: jonathan.lyons@nih.gov.
Abstract
OBJECTIVE: To aid the clinician in correctly interpreting serum tryptase levels. DATA SOURCES: Primary peer-reviewed literature. STUDY SELECTIONS: Clinical and basic science peer-reviewed studies characterizing the genetic and physiological bases for tryptase generation, secretion, and elevation, including those describing serum tryptase levels in population-based cohort studies. RESULTS: Clinically measured basal serum tryptase (BST) consists of ostensibly inactive alpha- and beta-tryptase precursors. The autosomal dominant genetic trait hereditary alpha-tryptasemia is the most often cause for elevated BST levels, with other acquired causes, such as renal failure and clonal myeloid diseases being far less common. Acute increases in serum tryptase levels resulting from release of mature tryptase from secretory granules is specific to mast cell degranulation but is not detected in all cases of systemic anaphylaxis. CONCLUSION: Understanding the differences and distinguishing between acute increases in serum tryptase and chronic elevations in BST owing to inherited or acquired conditions is critical in the correct interpretation of this useful clinical biomarker. Published by Elsevier Inc.
OBJECTIVE: To aid the clinician in correctly interpreting serum tryptase levels. DATA SOURCES: Primary peer-reviewed literature. STUDY SELECTIONS: Clinical and basic science peer-reviewed studies characterizing the genetic and physiological bases for tryptase generation, secretion, and elevation, including those describing serum tryptase levels in population-based cohort studies. RESULTS: Clinically measured basal serum tryptase (BST) consists of ostensibly inactive alpha- and beta-tryptase precursors. The autosomal dominant genetic trait hereditary alpha-tryptasemia is the most often cause for elevated BST levels, with other acquired causes, such as renal failure and clonal myeloid diseases being far less common. Acute increases in serum tryptase levels resulting from release of mature tryptase from secretory granules is specific to mast cell degranulation but is not detected in all cases of systemic anaphylaxis. CONCLUSION: Understanding the differences and distinguishing between acute increases in serum tryptase and chronic elevations in BST owing to inherited or acquired conditions is critical in the correct interpretation of this useful clinical biomarker. Published by Elsevier Inc.
Authors: W R Sperr; J H Jordan; M Baghestanian; H P Kiener; P Samorapoompichit; H Semper; A Hauswirth; G H Schernthaner; A Chott; S Natter; D Kraft; R Valenta; L B Schwartz; K Geissler; K Lechner; P Valent Journal: Blood Date: 2001-10-01 Impact factor: 22.113
Authors: M Molino; E S Barnathan; R Numerof; J Clark; M Dreyer; A Cumashi; J A Hoxie; N Schechter; M Woolkalis; L F Brass Journal: J Biol Chem Date: 1997-02-14 Impact factor: 5.157
Authors: Matthew P Giannetti; Cem Akin; Raied Hufdhi; Matthew J Hamilton; Emily Weller; Bjorn van Anrooij; Jonathan J Lyons; Jason L Hornick; Geraldine Pinkus; Mariana Castells; Olga Pozdnyakova Journal: J Allergy Clin Immunol Date: 2020-11-25 Impact factor: 10.793
Authors: Sarah C Glover; Melody C Carter; Peter Korošec; Patrizia Bonadonna; Lawrence B Schwartz; Joshua D Milner; George H Caughey; Dean D Metcalfe; Jonathan J Lyons Journal: Ann Allergy Asthma Immunol Date: 2021-08-13 Impact factor: 6.248