Hyaluronic Acid Soft Tissue Filler Delayed Inflammatory Reaction Following COVID-19 Vaccination - A Case Report.

The use of hyaluronic acid soft tissue fillers in aesthetic medicine exploded in recent years for many reasons, including being relatively safe. Incidence of delayed inflammatory reactions to hyaluronic acid soft tissue fillers range between 0.3 and 4.25%. These reactions are mediated by T-lymphocytes and can be triggered by flu-like illnesses, including SARS-CoV-2 infection. Vaccination may also induce hypersensitivity. In this case report, we present two cases of delayed reaction after hyaluronic acid soft tissue fillers treatment of the tear trough area and following mRNA vaccination against SARS-Cov-2, also known as COVID-19, months later. One case resolved spontaneously without intervention, and the other case resolved after one treatment session of hyaluronidase injection. Considering the ongoing pandemic and the worldwide demand for vaccines against COVID-19, the aesthetic providers should be conscious of the risks posed by the interaction of such vaccines in patients who previously had or seeking hyaluronic acid soft tissue filler injections. This article is protected by copyright. All rights reserved.