Dana Ivancovsky-Wajcman1, Naomi Fliss-Isakov2, Muriel Webb2,3, Itay Bentov4, Oren Shibolet2,3, Revital Kariv2,3, Shira Zelber-Sagi1,2. 1. School of Public Health, University of Haifa, Haifa, Israel. 2. Department of Gastroenterology, Tel Aviv Medical Center, Tel Aviv, Israel. 3. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 4. Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA, USA.
Abstract
BACKGROUND & AIMS: High consumption of ultra-processed food (UPF) is associated with mortality and chronic morbidity but has not been studied concerning to non-alcoholic fatty liver disease (NAFLD). We aimed to test the association of UPF consumption with metabolic syndrome, NAFLD and related-liver damage. METHODS: A cross-sectional study among volunteers who underwent abdominal ultrasound (AUS), anthropometrics, blood pressure measurements, and fasting blood tests including FibroMax for non-invasive assessment of NASH and significant fibrosis. A food-frequency questionnaire was used to evaluate UPF consumption using the NOVA classification. RESULTS: A total of 789 subjects were included in the total sample (mean age 58.83 ± 6.58 years, 52.60% men), a reliable FibroMax test was obtained from 714 subjects, 305 subjects were diagnosed with NAFLD. High consumption of UPF was associated with higher odds for metabolic syndrome (OR = 1.88, 95% CI 1.31-2.71, P = .001) and its components; hypertension, hypertriglyceridemia, and low HDL, among the entire sample (OR = 1.53, 1.07-2.19, P = .026; OR = 1.51, 1.08-2.11, P = .017; OR = 1.55, 1.05-2.29, P = .028). In addition, it was associated with higher odds for NASH and hypertension (OR = 1.89, 1.07-3.38, P = .030; OR = 2.26, 1.20-4.26, P = .012 respectively) among subjects with NAFLD. Stratification by smoking status revealed an association between high UPF consumption and significant fibrosis among ever smokers in the entire sample and among subjects with NAFLD (OR = 1.89, 95% CI 1.03-3.45, P = .039; OR = 2.85, 1.14-7.14, P = .026 respectively). CONCLUSIONS: High UPF consumption is associated with metabolic syndrome in the general population, and among those with NAFLD it is associated with NASH marker. Ever-smoking may act synergistically with UPF to amplify the risk for fibrosis.
BACKGROUND & AIMS: High consumption of ultra-processed food (UPF) is associated with mortality and chronic morbidity but has not been studied concerning to non-alcoholic fatty liver disease (NAFLD). We aimed to test the association of UPF consumption with metabolic syndrome, NAFLD and related-liver damage. METHODS: A cross-sectional study among volunteers who underwent abdominal ultrasound (AUS), anthropometrics, blood pressure measurements, and fasting blood tests including FibroMax for non-invasive assessment of NASH and significant fibrosis. A food-frequency questionnaire was used to evaluate UPF consumption using the NOVA classification. RESULTS: A total of 789 subjects were included in the total sample (mean age 58.83 ± 6.58 years, 52.60% men), a reliable FibroMax test was obtained from 714 subjects, 305 subjects were diagnosed with NAFLD. High consumption of UPF was associated with higher odds for metabolic syndrome (OR = 1.88, 95% CI 1.31-2.71, P = .001) and its components; hypertension, hypertriglyceridemia, and low HDL, among the entire sample (OR = 1.53, 1.07-2.19, P = .026; OR = 1.51, 1.08-2.11, P = .017; OR = 1.55, 1.05-2.29, P = .028). In addition, it was associated with higher odds for NASH and hypertension (OR = 1.89, 1.07-3.38, P = .030; OR = 2.26, 1.20-4.26, P = .012 respectively) among subjects with NAFLD. Stratification by smoking status revealed an association between high UPF consumption and significant fibrosis among ever smokers in the entire sample and among subjects with NAFLD (OR = 1.89, 95% CI 1.03-3.45, P = .039; OR = 2.85, 1.14-7.14, P = .026 respectively). CONCLUSIONS: High UPF consumption is associated with metabolic syndrome in the general population, and among those with NAFLD it is associated with NASH marker. Ever-smoking may act synergistically with UPF to amplify the risk for fibrosis.
Authors: Martina De Siena; Pauline Raoul; Lara Costantini; Emidio Scarpellini; Marco Cintoni; Antonio Gasbarrini; Emanuele Rinninella; Maria Cristina Mele Journal: Foods Date: 2022-07-25
Authors: Jadwiga Konieczna; Miguel Fiol; Antoni Colom; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; María Trinidad Soria-Florido; J Alfredo Martínez; Ángel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; José López-Miranda; Ramon Estruch; M Rosa Bernal-López; José Lapetra; Lluís Serra-Majem; Aurora Bueno-Cavanillas; Josep A Tur; Vicente Martín Sánchez; Xavier Pintó; José J Gaforio; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Lidia Daimiel; Emilio Ros; Maira Bes-Rastrollo; María Pascual; Jose V Sorlí; Albert Goday; María Ángeles Zulet; Anai Moreno-Rodriguez; Francisco Jesús Carmona González; Rafael Valls-Enguix; Juana M Janer; Antonio Garcia-Rios; Rosa Casas; Ana M Gomez-Perez; José Manuel Santos-Lozano; F Javier Basterra-Gortari; María Ángeles Martínez; Carolina Ortega-Azorin; Joan Bayó; Itziar Abete; Itziar Salaverria-Lete; Miguel Ruiz-Canela; Nancy Babio; Lourdes Carres; Dora Romaguera Journal: Nutrients Date: 2022-10-05 Impact factor: 6.706