Liling Chen1, Zhidong Huang2, Weiguo Li1, Yibo He2, Jingjing Liang3, Jin Lu1, Yanfang Yang1, Haozhang Huang3, Yihang Lin2, Rongwen Lin1, Mengfei Lin4, Yan Liang4, Yunzhao Hu5, Jianfeng Ye6, Yuying Hu7, Jin Liu2, Yong Liu2,3,8, Yong Fang9, Kaihong Chen10, Shiqun Chen11. 1. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. 2. Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. 3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China. 4. Maoming People's Hospital, Maoming, China. 5. Shunde Hospital of Southern Medical University, Shunde, China. 6. Department of Cardiology, Dongguan TCM Hospital, Dongguan, 523209, China. 7. Department of Cardiology, First People's Hospital of Kashgar, Kashgar, 844000, China. 8. Department of Information Technology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. 9. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. fy7008@163.com. 10. Department of Cardiology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China. chenkaihong1964@163.com. 11. Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China. shiqunchen@126.com.
Abstract
PURPOSE: Malnutrition is a common comorbidity of coronary artery disease (CAD) and is often associated with adverse events. The malnutrition often means lower cholesterol, albumin and high lymphocyte, as risk factors of Contrast-Induced Acute Kidney Injury (CI-AKI). We aim to evaluate the association between malnutrition and CI-AKI following coronary angiography (CAG) in CAD patients. METHODS: We analyzed 3170 CAD patients with variables of nutritional status (Controlling Nutritional Status score (CONUT)) from the prospective multicenter study, REICIN (NCT01402232) including 4,271 consecutive patients undergoing CAG from January 2013 to February 2016. Patients were divided into the normal group (CONUT score 0-1) and malnutrition group (CONUT score > 1). The association of malnutrition and the risk of CI-AKI was examined in all CAD patients using multivariable logistics regression analysis. RESULTS: Among the 3170 patients (mean age: 63.1 ± 10.7 years), 1865 (58.8%) suffered from malnutrition, 111 (3.5%) developed CI-AKI, including 23 (1.76%) in normal group and 88 (4.72%) in malnutrition group (p < 0.01). The malnourished patients were older, and likely had anemia and worse cardiorenal function. After adjustment for confounders, the risk of CI-AKI was 1.04 times higher in the malnutrition group than in the normal group (adjusted OR: 2.04, 95% CI 1.28-3.38, p < 0.01). CONCLUSIONS: Among CAD patients undergoing CAG, malnutrition is extremely common and associated with a double risk of CI-AKI. Further studies are needed to investigate the potential renal protection of intervening malnutrition in CAD patients.
PURPOSE: Malnutrition is a common comorbidity of coronary artery disease (CAD) and is often associated with adverse events. The malnutrition often means lower cholesterol, albumin and high lymphocyte, as risk factors of Contrast-Induced Acute Kidney Injury (CI-AKI). We aim to evaluate the association between malnutrition and CI-AKI following coronary angiography (CAG) in CAD patients. METHODS: We analyzed 3170 CAD patients with variables of nutritional status (Controlling Nutritional Status score (CONUT)) from the prospective multicenter study, REICIN (NCT01402232) including 4,271 consecutive patients undergoing CAG from January 2013 to February 2016. Patients were divided into the normal group (CONUT score 0-1) and malnutrition group (CONUT score > 1). The association of malnutrition and the risk of CI-AKI was examined in all CAD patients using multivariable logistics regression analysis. RESULTS: Among the 3170 patients (mean age: 63.1 ± 10.7 years), 1865 (58.8%) suffered from malnutrition, 111 (3.5%) developed CI-AKI, including 23 (1.76%) in normal group and 88 (4.72%) in malnutrition group (p < 0.01). The malnourished patients were older, and likely had anemia and worse cardiorenal function. After adjustment for confounders, the risk of CI-AKI was 1.04 times higher in the malnutrition group than in the normal group (adjusted OR: 2.04, 95% CI 1.28-3.38, p < 0.01). CONCLUSIONS: Among CAD patients undergoing CAG, malnutrition is extremely common and associated with a double risk of CI-AKI. Further studies are needed to investigate the potential renal protection of intervening malnutrition in CAD patients.
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Authors: Roosa Lankinen; Markus Hakamäki; Kaj Metsärinne; Niina Koivuviita; Jussi P Pärkkä; Maria Saarenhovi; Tapio Hellman; Mikko J Järvisalo Journal: BMC Nephrol Date: 2021-02-04 Impact factor: 2.388