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Literature DB >> 3417313

Recurrent genomic rearrangements are not at the fragile sites on chromosomes 3 and 5 in human renal cell carcinomas.

Abstract

It has been suggested that fragile sites on human chromosomes predispose to specific rearrangements seen in cancer. Renal cell carcinoma is characterised by recurrent aberrations of chromosome 3p and frequent rearrangements of chromosome 5q. To investigate whether there might be an association between fragile sites and recurrent breakpoints in renal cell carcinoma, we have determined the breakpoints observed in 50 tumours and compared them to the known fragile sites on chromosomes 3 and 5. No correlation between fragile sites and cancer-related breakpoints in renal cell carcinomas was found.

Entities: Disease Species

Mesh：

Year: 1988 PMID： 3417313 DOI： 10.1007/BF00451467

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

15 in total

1. Recessive mutant genes predisposing to human cancer.

Authors: W K Cavenee; A Koufos; M F Hansen
Journal: Mutat Res Date: 1986-07 Impact factor: 2.433

2. Fragile sites are targets of diverse mutagens and carcinogens.

Authors: J J Yunis; A L Soreng; A E Bowe
Journal: Oncogene Date: 1987-03 Impact factor: 9.867

3. Nineteen of 26 cellular oncogenes precisely localized in the human genome map to one of the 83 bands involved in primary cancer-specific rearrangements.

Authors: S Heim; F Mitelman
Journal: Hum Genet Date: 1987-01 Impact factor: 4.132

Recurrent genomic rearrangements are not at the fragile sites on chromosomes 3 and 5 in human renal cell carcinomas.

1. Recessive mutant genes predisposing to human cancer.

2. Fragile sites are targets of diverse mutagens and carcinogens.

3. Nineteen of 26 cellular oncogenes precisely localized in the human genome map to one of the 83 bands involved in primary cancer-specific rearrangements.

Review 4. Chromosomal fragile sites and cancer-specific rearrangements.

5. Chromosomes in kidney, ureter, and bladder cancer.

6. Abnormalities at chromosome region 3p12-14 characterize clear cell renal carcinoma.

7. Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL.

8. Cytogenetic studies of tumor tissue from patients with nonfamilial renal cell carcinoma.

9. Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders.

10. Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma.

Review 1. Renal cell carcinoma deep sequencing: recent developments.