Literature DB >> 34173105

Spike Activity in the Ventromedial Nucleus of Rat Hypothalamus during Aging.

K Yu Moiseev1, A A Spirichev1, L G Pankrasheva1, A S Martyusheva2, A Yu Abramova2, P M Maslyukov3.   

Abstract

Spike activity of neurons in the ventromedial nucleus (VMN) of the hypothalamus in adult (6-8 months) and aged (2 years) male rats was studied by the in vivo extracellular method using stereotaxic insertion of microelectrodes. In all animals, firing frequency of most VMN neurons increased in response to glucose administration. However, in aged rats, the mean baseline and glucose-induced spike frequencies of VMN neurons were lower than in adult animals. These results support the hypothesis that aging is associated with a decrease in the functional activity of hypothalamic neurons.

Entities:  

Keywords:  aging; hypothalamus; spike frequency; ventromedial nucleus

Mesh：

Substances：

Year:  2021        PMID： 34173105     DOI： 10.1007/s10517-021-05205-4

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

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