Zixu Wang1, Fengyan Lu2, Xing Li3, Yanni Guo4, Jiajing Li1, Li He1. 1. Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China. 2. Department of Dermatology, Qujing Affiliated Hospital of Kunming Medical University, Qujing, China. 3. Department of Dermatology, People's Hospital of Chuxiong Yi Autonomous Prefecture, Chuxiong, China. 4. Department of Dermatology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Abstract
BACKGROUND: Melasma is a common disorder manifested by symmetric hyperpigmentation of sun-exposed skin. Although ultraviolet (UV) radiation is a known risk factor of melasma, whether skin sensitivities to UVA and/or UVB differ between healthy controls and female patients with melasma is unknown. METHODS: Minimal erythema dose (MED)-UVA and MED-UVB results were compared between female patients with melasma and healthy controls. Additionally, relationships between MED values and Melasma Area and Severity Index (MASI) scores, and skin color were assessed. RESULTS: The melasma and control groups included 142 and 137 subjects, respectively. Compared with healthy control group, our melasma group had lower MED-UVA (P < .001) and MED-UVB (P < .05). MASI scores were negatively correlated with MED-UVA and MED-UVB (P < .001). Additionally, Skin a* values in melasma-involved skin were negatively correlated with MED-UVA (P < .05). Skin b* values in melasma-involved skin were negatively correlated with MED-UVB and MED-UVA (P < .05). CONCLUSIONS: Patients with melasma exhibit a low MED to both UVA and UVB, rendering them have a predisposition to an increased UV sensitivity. Because of the association between melasma and UV sensitivity, sun exposure should be avoided to alleviate or prevent melasma.
BACKGROUND: Melasma is a common disorder manifested by symmetric hyperpigmentation of sun-exposed skin. Although ultraviolet (UV) radiation is a known risk factor of melasma, whether skin sensitivities to UVA and/or UVB differ between healthy controls and female patients with melasma is unknown. METHODS: Minimal erythema dose (MED)-UVA and MED-UVB results were compared between female patients with melasma and healthy controls. Additionally, relationships between MED values and Melasma Area and Severity Index (MASI) scores, and skin color were assessed. RESULTS: The melasma and control groups included 142 and 137 subjects, respectively. Compared with healthy control group, our melasma group had lower MED-UVA (P < .001) and MED-UVB (P < .05). MASI scores were negatively correlated with MED-UVA and MED-UVB (P < .001). Additionally, Skin a* values in melasma-involved skin were negatively correlated with MED-UVA (P < .05). Skin b* values in melasma-involved skin were negatively correlated with MED-UVB and MED-UVA (P < .05). CONCLUSIONS: Patients with melasma exhibit a low MED to both UVA and UVB, rendering them have a predisposition to an increased UV sensitivity. Because of the association between melasma and UV sensitivity, sun exposure should be avoided to alleviate or prevent melasma.
Authors: Santina Conte; Feras M Ghazawi; Michelle Le; Hacene Nedjar; Akram Alakel; François Lagacé; Ilya M Mukovozov; Janelle Cyr; Ahmed Mourad; Wilson H Miller; Joël Claveau; Thomas G Salopek; Elena Netchiporouk; Robert Gniadecki; Denis Sasseville; Elham Rahme; Ivan V Litvinov Journal: Front Med (Lausanne) Date: 2022-03-03
Authors: Ana Cláudia C Espósito; Daniel P Cassiano; Carolina N da Silva; Paula B Lima; Joana A F Dias; Karime Hassun; Ediléia Bagatin; Luciane D B Miot; Hélio Amante Miot Journal: Dermatol Ther (Heidelb) Date: 2022-07-29