Literature DB >> 34170220

Prevalence of sleepiness and associations with quality of life in patients with sleep apnea in an online cohort.

Lindsey J Wanberg1, Rebecca E Rottapel1, Michelle L Reid1, Suzanne M Bertisch1,2, Morgan Bron3, Vishesh K Kapur4, Shay Bujanover3, Zinta Harrington5, Jessie P Bakker1,2, Sogol Javaheri1,2, Mark Hanson6, Kathleen Figetakis6, Kathy Page6, Sherry Hanes6, Kathleen F Villa3, Susan Redline1,2.   

Abstract

STUDY
OBJECTIVES: Excessive daytime sleepiness (EDS) is a treatment target for many patients with obstructive sleep apnea (OSA). We aimed to understand the prevalence, risk factors, and quality of life associated with EDS in a nonclinical, "real world" sample of patients with OSA.
METHODS: Cross-sectional survey of patients with OSA participating in an online peer support community, assessing demographics, comorbidities, treatment, and quality of life. Differences in those with and without EDS (Epworth Sleepiness Scale > and ≤ 10) were assessed.
RESULTS: The sample (n = 422) was 54.2% male, 65.9% were ≥ 55 years, and 43.3% reported sleeping ≤ 6 hours/night. EDS was identified among 31.0% of respondents and 51.7% reported sleepiness as a precipitating factor for seeking initial OSA treatment. EDS was more prevalent in individuals reporting asthma, insomnia symptoms, positive airway pressure (PAP) use less than 6 hours/night on ≥ 5 nights/week, or sleep duration < 6 hours/night. After adjusting for demographics and comorbidities, patients with EDS reported poorer mental and physical health and well-being, lower disease-specific functional status, more activity and work impairment, and more driving impairment (P values < .05). In the subsample (n = 265) with high PAP adherence, 26.0% reported EDS, and similar associations between EDS and outcomes were observed.
CONCLUSIONS: These "real world" data suggest that patients seeking online OSA support experience a high prevalence of EDS, which was associated with poorer quality of life and worse functional status. Associations persisted among respondents with high self-reported PAP-therapy adherence, potentially driving these individuals to seek online support for sleepiness-related symptoms. CITATION: Wanberg LJ, Rottapel RE, Reid ML, et al. Prevalence of sleepiness and associations with quality of life in patients with sleep apnea in an online cohort. J Clin Sleep Med. 2021;17(12):2363-2372.
© 2021 American Academy of Sleep Medicine.

Entities:  

Keywords:  excessive daytime sleepiness; online; quality of life; sleep apnea

Mesh:

Year:  2021        PMID: 34170220      PMCID: PMC8726384          DOI: 10.5664/jcsm.9436

Source DB:  PubMed          Journal:  J Clin Sleep Med        ISSN: 1550-9389            Impact factor:   4.062


  41 in total

1.  Sleepiness in patients with moderate to severe sleep-disordered breathing.

Authors:  Vishesh K Kapur; Carol M Baldwin; Helaine E Resnick; Daniel J Gottlieb; F Javier Nieto
Journal:  Sleep       Date:  2005-04       Impact factor: 5.849

2.  Recognition and consequences of obstructive sleep apnea hypopnea syndrome

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Journal:  Otolaryngol Clin North Am       Date:  1999-04       Impact factor: 3.346

3.  Determining the level of sleepiness in the American population and its correlates.

Authors:  Maurice M Ohayon
Journal:  J Psychiatr Res       Date:  2012-01-31       Impact factor: 4.791

4.  Association of insomnia with quality of life, work productivity, and activity impairment.

Authors:  Susan C Bolge; Justin F Doan; Hema Kannan; Robert W Baran
Journal:  Qual Life Res       Date:  2009-03-14       Impact factor: 4.147

5.  Predictors of residual sleepiness in adequately treated obstructive sleep apnoea patients.

Authors:  I Koutsourelakis; E Perraki; N T Economou; P Dimitrokalli; E Vagiakis; C Roussos; S Zakynthinos
Journal:  Eur Respir J       Date:  2009-04-08       Impact factor: 16.671

6.  Reliability and factor analysis of the Epworth Sleepiness Scale.

Authors:  M W Johns
Journal:  Sleep       Date:  1992-08       Impact factor: 5.849

7.  Long-term intermittent hypoxia: reduced excitatory hypoglossal nerve output.

Authors:  Sigrid C Veasey; Guanxia Zhan; Polina Fenik; Domenico Pratico
Journal:  Am J Respir Crit Care Med       Date:  2004-06-30       Impact factor: 21.405

Review 8.  Update on Persistent Excessive Daytime Sleepiness in OSA.

Authors:  Sogol Javaheri; Shahrokh Javaheri
Journal:  Chest       Date:  2020-03-06       Impact factor: 9.410

9.  A multicentre randomised controlled trial and economic evaluation of continuous positive airway pressure for the treatment of obstructive sleep apnoea syndrome in older people: PREDICT.

Authors:  Alison McMillan; Daniel J Bratton; Rita Faria; Magda Laskawiec-Szkonter; Susan Griffin; Robert J Davies; Andrew J Nunn; John R Stradling; Renata L Riha; Mary J Morrell
Journal:  Health Technol Assess       Date:  2015-06       Impact factor: 4.014

10.  Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.

Authors:  Heming Wang; Jacqueline M Lane; Samuel E Jones; Hassan S Dashti; Hanna M Ollila; Andrew R Wood; Vincent T van Hees; Ben Brumpton; Bendik S Winsvold; Katri Kantojärvi; Teemu Palviainen; Brian E Cade; Tamar Sofer; Yanwei Song; Krunal Patel; Simon G Anderson; David A Bechtold; Jack Bowden; Richard Emsley; Simon D Kyle; Max A Little; Andrew S Loudon; Frank A J L Scheer; Shaun M Purcell; Rebecca C Richmond; Kai Spiegelhalder; Jessica Tyrrell; Xiaofeng Zhu; Christer Hublin; Jaakko A Kaprio; Kati Kristiansson; Sonja Sulkava; Tiina Paunio; Kristian Hveem; Jonas B Nielsen; Cristen J Willer; John-Anker Zwart; Linn B Strand; Timothy M Frayling; David Ray; Deborah A Lawlor; Martin K Rutter; Michael N Weedon; Susan Redline; Richa Saxena
Journal:  Nat Commun       Date:  2019-08-13       Impact factor: 14.919

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  1 in total

1.  Comorbid obstructive sleep apnea and insomnia and its associations with mood and diabetes-related distress in type 2 diabetes mellitus.

Authors:  Bomin Jeon; Faith S Luyster; Susan M Sereika; Monica M DiNardo; Judith A Callan; Eileen R Chasens
Journal:  J Clin Sleep Med       Date:  2022-04-01       Impact factor: 4.062

  1 in total

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