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Literature DB >> 34170198

The chicken, the egg, and the elephant: eNOS and NRG1 in fibrosis.

Shamama Nishat^1,2, Richard J Gumina^1,2,3.

Abstract

Entities: Chemical

Keywords: fibrosis; neuregulin; nitric oxide

Mesh：

Substances：

Year: 2021 PMID： 34170198 PMCID： PMC8410117 DOI： 10.1152/ajpheart.00308.2021

Source DB: PubMed Journal: Am J Physiol Heart Circ Physiol ISSN： 0363-6135 Impact factor: 5.125

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10 in total

1. Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.

Authors: Annet Kirabo; Sergey Ryzhov; Manisha Gupte; Seng Sengsayadeth; Richard J Gumina; Douglas B Sawyer; Cristi L Galindo
Journal: J Mol Cell Cardiol Date: 2017-03-03 Impact factor: 5.000

2. Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency.

Authors: Hadis Shakeri; Jente R A Boen; Sofie De Moudt; Jhana O Hendrickx; Arthur J A Leloup; Griet Jacobs; Guido R Y De Meyer; Gilles W De Keulenaer; Pieter-Jan D F Guns; Vincent F M Segers
Journal: Am J Physiol Heart Circ Physiol Date: 2021-05-14 Impact factor: 4.733

3. Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure.

Authors: S D Katz; T Khan; G A Zeballos; L Mathew; P Potharlanka; M Knecht; J Whelan
Journal: Circulation Date: 1999-04-27 Impact factor: 29.690

4. Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung.

Authors: Zarha Vermeulen; Anne-Sophie Hervent; Lindsey Dugaucquier; Leni Vandekerckhove; Miche Rombouts; Matthias Beyens; Dorien M Schrijvers; Guido R Y De Meyer; Stuart Maudsley; Gilles W De Keulenaer; Vincent F M Segers
Journal: Am J Physiol Heart Circ Physiol Date: 2017-08-19 Impact factor: 4.733

The chicken, the egg, and the elephant: eNOS and NRG1 in fibrosis.

1. Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.

2. Neuregulin-1 compensates for endothelial nitric oxide synthase deficiency.

3. Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failure.

4. Inhibitory actions of the NRG-1/ErbB4 pathway in macrophages during tissue fibrosis in the heart, skin, and lung.

Review 5. The renin-angiotensin-aldosterone system: a crossroad from arterial hypertension to heart failure.

6. The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling.

7. Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase.

Review 8. Rethinking Endothelial Dysfunction as a Crucial Target in Fighting Heart Failure.

9. Circulating neuregulin1-β in heart failure with preserved and reduced left ventricular ejection fraction.

Review 10. Neuregulins: protective and reparative growth factors in multiple forms of cardiovascular disease.