Literature DB >> 34168346

CRISPR base editing lowers cholesterol in monkeys.

Sebastiaan Johannes van Kampen1, Eva van Rooij2,3.   

Abstract

Entities:  

Year:  2021        PMID： 34168346     DOI： 10.1038/s41587-021-00975-8

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  3 in total

1.  Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.

Authors:  Shuai Jin; Yuan Zong; Qiang Gao; Zixu Zhu; Yanpeng Wang; Peng Qin; Chengzhi Liang; Daowen Wang; Jin-Long Qiu; Feng Zhang; Caixia Gao
Journal:  Science       Date:  2019-02-28       Impact factor: 47.728

2.  Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

Authors:  Erwei Zuo; Yidi Sun; Wu Wei; Tanglong Yuan; Wenqin Ying; Hao Sun; Liyun Yuan; Lars M Steinmetz; Yixue Li; Hui Yang
Journal:  Science       Date:  2019-02-28       Impact factor: 47.728

3.  In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.

Authors:  Tanja Rothgangl; Melissa K Dennis; Paulo J C Lin; Rurika Oka; Dominik Witzigmann; Lukas Villiger; Weihong Qi; Martina Hruzova; Lucas Kissling; Daniela Lenggenhager; Costanza Borrelli; Sabina Egli; Nina Frey; Noëlle Bakker; John A Walker; Anastasia P Kadina; Denis V Victorov; Martin Pacesa; Susanne Kreutzer; Zacharias Kontarakis; Andreas Moor; Martin Jinek; Drew Weissman; Markus Stoffel; Ruben van Boxtel; Kevin Holden; Norbert Pardi; Beat Thöny; Johannes Häberle; Ying K Tam; Sean C Semple; Gerald Schwank
Journal:  Nat Biotechnol       Date:  2021-05-19       Impact factor: 54.908
  3 in total
  1 in total

Review 1.  PCSK9 Monoclonal Antibodies: New Developments and Their Relevance in a Nucleic Acid-Based Therapy Era.

Authors:  Ioanna Gouni-Berthold; Jonas Schwarz; Heiner K Berthold
Journal:  Curr Atheroscler Rep       Date:  2022-07-28       Impact factor: 5.967
  1 in total

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