X Liu1,2, H Haraldsson2, Y Wang3,4, E Kao2, M Ballweber2, A J Martin2, C E McCulloch2, F Faraji2, D Saloner2. 1. From the Department of Interventional Neuroradiology (X.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 2. Departments of Radiology and Biomedical Imaging, and Epidemiology and Biostatistics (X.L., H.H., Y.W., E.K., M.B., A.J.M., C.E.M., F.F., D.S), University of California San Francisco, San Francisco, Californa. 3. Departments of Radiology and Biomedical Imaging, and Epidemiology and Biostatistics (X.L., H.H., Y.W., E.K., M.B., A.J.M., C.E.M., F.F., D.S), University of California San Francisco, San Francisco, Californa wangyuting_330@163.com. 4. Department of Radiology (Y.W.), Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Abstract
BACKGROUND AND PURPOSE: The reliability of contrast-enhanced MRA in monitoring serial volumetric changes of unruptured intracranial aneurysms has not been established. We aimed to determine the coefficient of variance of contrast-enhanced MRA in measuring aneurysm volumes, thus establishing criteria for aneurysm growth and permitting identification of variables predictive of growth. MATERIALS AND METHODS: Aneurysm volumes were measured from serial contrast-enhanced MRA studies of patients with untreated intracranial aneurysms who underwent >2 sequential MR imaging evaluations. After coregistering all sequential studies in 3D space for each aneurysm and signal intensity normalization, aneurysm volume was determined across all time points. A linear mixed effects model was built to estimate the coefficient of variance of the measurement as well as to determine predictive variables. Growth was defined as relative growth exceeding 2 times the measurement coefficient of variance (sudden growth, as 4 times the coefficient of variance). RESULTS: A total of 95 patients with 112 aneurysms were included (5.9 scans during 4.0 years on average, 616 scan measurements in total). The coefficient of variance was 5.5% of the aneurysm volume, and the relative growth rate was dependent on the location: anterior cerebral artery, 4.52% per year; vertebral artery, 2.46% per year; middle cerebral artery, 2.74% per year; basilar artery, 2.36% per year; internal carotid artery, 1.14% per year. Thirty-six of 112 (32%) aneurysms were characterized as growing, and 11/36 of them had an episode of sudden growth. CONCLUSIONS: Volume measurement of unruptured intracranial aneurysms by contrast-enhanced MRA seems a reliable metric for tracking the growth trajectory of aneurysms. Furthermore, the aneurysm growth rate differs among different locations.
BACKGROUND AND PURPOSE: The reliability of contrast-enhanced MRA in monitoring serial volumetric changes of unruptured intracranial aneurysms has not been established. We aimed to determine the coefficient of variance of contrast-enhanced MRA in measuring aneurysm volumes, thus establishing criteria for aneurysm growth and permitting identification of variables predictive of growth. MATERIALS AND METHODS: Aneurysm volumes were measured from serial contrast-enhanced MRA studies of patients with untreated intracranial aneurysms who underwent >2 sequential MR imaging evaluations. After coregistering all sequential studies in 3D space for each aneurysm and signal intensity normalization, aneurysm volume was determined across all time points. A linear mixed effects model was built to estimate the coefficient of variance of the measurement as well as to determine predictive variables. Growth was defined as relative growth exceeding 2 times the measurement coefficient of variance (sudden growth, as 4 times the coefficient of variance). RESULTS: A total of 95 patients with 112 aneurysms were included (5.9 scans during 4.0 years on average, 616 scan measurements in total). The coefficient of variance was 5.5% of the aneurysm volume, and the relative growth rate was dependent on the location: anterior cerebral artery, 4.52% per year; vertebral artery, 2.46% per year; middle cerebral artery, 2.74% per year; basilar artery, 2.36% per year; internal carotid artery, 1.14% per year. Thirty-six of 112 (32%) aneurysms were characterized as growing, and 11/36 of them had an episode of sudden growth. CONCLUSIONS: Volume measurement of unruptured intracranial aneurysms by contrast-enhanced MRA seems a reliable metric for tracking the growth trajectory of aneurysms. Furthermore, the aneurysm growth rate differs among different locations.
Authors: A Stijntje E Bor; Andreas T Tiel Groenestege; Karel G terBrugge; Ronit Agid; Birgitta K Velthuis; Gabriel J E Rinkel; Marieke J H Wermer Journal: Stroke Date: 2014-11-13 Impact factor: 7.914
Authors: J Pablo Villablanca; Gary R Duckwiler; Reza Jahan; Satoshi Tateshima; Neil A Martin; John Frazee; Nestor R Gonzalez; James Sayre; Fernando V Vinuela Journal: Radiology Date: 2013-07-02 Impact factor: 11.105
Authors: Jacoba P Greving; Marieke J H Wermer; Robert D Brown; Akio Morita; Seppo Juvela; Masahiro Yonekura; Toshihiro Ishibashi; James C Torner; Takeo Nakayama; Gabriël J E Rinkel; Ale Algra Journal: Lancet Neurol Date: 2013-11-27 Impact factor: 44.182
Authors: Nima Etminan; Kerim Beseoglu; Daniel L Barrow; Joshua Bederson; Robert D Brown; E Sander Connolly; Colin P Derdeyn; Daniel Hänggi; David Hasan; Seppo Juvela; Hidetoshi Kasuya; Peter J Kirkpatrick; Neville Knuckey; Timo Koivisto; Giuseppe Lanzino; Michael T Lawton; Peter LeRoux; Cameron G McDougall; Edward Mee; J Mocco; Andrew Molyneux; Michael K Morgan; Kentaro Mori; Akio Morita; Yuichi Murayama; Shinji Nagahiro; Alberto Pasqualin; Andreas Raabe; Jean Raymond; Gabriel J E Rinkel; Daniel Rüfenacht; Volker Seifert; Julian Spears; Hans-Jakob Steiger; Helmuth Steinmetz; James C Torner; Peter Vajkoczy; Isabel Wanke; George K C Wong; John H Wong; R Loch Macdonald Journal: Stroke Date: 2014-03-25 Impact factor: 7.914
Authors: Rob Molenberg; Marlien W Aalbers; Auke P A Appelman; Maarten Uyttenboogaart; J Marc C van Dijk Journal: Eur J Neurol Date: 2021-08-25 Impact factor: 6.288